Evidence map›Paper›PMID 40372690›Full record

ArticleJournal of endocrinological investigation2025

Role of thyroid function in non-basal ganglia intracerebral hemorrhage prognosis.

Yiting Xu, Zirui Xu, Yang Chen, Junjie Yang, Kezheng Li, Yinuo Chen, Jiali Xie, Chunyang Pang, Lingfei Gao, Mengwan Song and 3 more

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Article in Journal of endocrinological investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

13 authors.

Yiting XuDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
Zirui XuFirst Clinical College of Wenzhou Medical University, Wenzhou, People's Republic of China.
Yang ChenFirst Clinical College of Wenzhou Medical University, Wenzhou, People's Republic of China.
Junjie YangFirst Clinical College of Wenzhou Medical University, Wenzhou, People's Republic of China.
Kezheng LiFirst Clinical College of Wenzhou Medical University, Wenzhou, People's Republic of China.
Yinuo ChenFirst Clinical College of Wenzhou Medical University, Wenzhou, People's Republic of China.
Jiali XieFirst Clinical College of Wenzhou Medical University, Wenzhou, People's Republic of China.
Chunyang PangDepartment of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
Lingfei GaoDepartment of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
Mengwan SongDepartment of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
Huan YuDepartment of Pediatrics, Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
Binbin DengDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China. dbinbin@aliyun.com.ORCID http://orcid.org/0000-0002-4058-0738
Huanjie HuangDepartment of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China. hhuanjie@163.com.

Funding

National Natural Science Foundation of China 81901273)Science and Technology Program of Zhejiang Province KY2023R036
6 · The paper itself

Abstract

purposeThyroid function disorders serve as unfavorable prognosis predictors for numerous diseases. However, their role in predicting intracerebral hemorrhage outcome is unclear. This study investigated the prognostic potential of thyroid function parameters for intracerebral hemorrhage.

methodsAdmissions for intracerebral hemorrhage caused by hypertension were retrospectively enrolled to determine thyroid function levels. Patients were subjected to three month- and three year-follow up to assess short- and long-term prognosis, respectively.

resultsElevated levels of thyroxine and decreased levels of free triiodothyronine (fT3) are associated with unfavorable short-term prognosis in non-basal ganglia intracerebral hemorrhage patients. The levels of thyroid stimulating hormone and free tetraiodothyronine did not exhibit any significant change. This alteration in thyroid function was not observed in basal-ganglia intracerebral hemorrhage patients. Furthermore, the inclusion of thyroxine and fT3 enhanced the prognostic power of the traditional model (NIHSS only) in predicting short-term outcomes. Among patients 55 years or older, subgroup analyses results are consistent with previous findings. Additionally, our clinical model is also applicable towards predicting the long-term prognosis of non-basal ganglia intracerebral hemorrhage.

conclusionThyroid function concentrations, especially the levels of thyroxine and fT3, could serve as key prognostic predictors for non-basal ganglia cerebral hemorrhage, especially among the middle-aged and elderly groups.

Indexed as

Cerebral HemorrhageThyroid GlandThyroxineTriiodothyronineAdultAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisRetrospective StudiesThyroid Function TestsThyroxineTriiodothyronineClinical modelIntracerebral hemorrhageNon-basal gangliaPrognosisThyroid function

Identifiers

PMID40372690

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