Evidence map›Paper›PMID 40372621›Full record

ArticleDrugs - real world outcomes2025

Treatment Pattern of Heart Failure Patients in Sweden During 2021-2023 in Relation to Updated Treatment Recommendations.

Michaela Eklund, Magnus Husberg, Therese Eriksson, Mattias Enoksson, Staffan Gustavsson, Lars-Åke Levin, Lars Bernfort

Abstract read
In one paragraph

Article in Drugs - real world outcomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Michaela EklundUnit of Healthcare Analysis, Center for Medical Technology Assessment, Department of Health, Medicine and Caring Sciences, Faculty of Medical and Health Sciences, Linköping University, Sandbäcksgatan 7, 581 83, Linköping, Sweden. michaela.eklund@liu.se.ORCID http://orcid.org/0009-0007-7931-8941
Magnus HusbergUnit of Healthcare Analysis, Center for Medical Technology Assessment, Department of Health, Medicine and Caring Sciences, Faculty of Medical and Health Sciences, Linköping University, Sandbäcksgatan 7, 581 83, Linköping, Sweden.
Therese ErikssonUnit of Healthcare Analysis, Center for Medical Technology Assessment, Department of Health, Medicine and Caring Sciences, Faculty of Medical and Health Sciences, Linköping University, Sandbäcksgatan 7, 581 83, Linköping, Sweden.
Mattias EnokssonBoehringer Ingelheim AB, Stockholm, Sweden.
Staffan GustavssonBoehringer Ingelheim AB, Stockholm, Sweden.
Lars-Åke LevinUnit of Healthcare Analysis, Center for Medical Technology Assessment, Department of Health, Medicine and Caring Sciences, Faculty of Medical and Health Sciences, Linköping University, Sandbäcksgatan 7, 581 83, Linköping, Sweden.
Lars BernfortUnit of Healthcare Analysis, Center for Medical Technology Assessment, Department of Health, Medicine and Caring Sciences, Faculty of Medical and Health Sciences, Linköping University, Sandbäcksgatan 7, 581 83, Linköping, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn early 2022, new treatment recommendations for heart failure (HF) were introduced in Sweden.

objectiveThis study aims to evaluate and analyze the pharmaceutical treatment patterns of HF patients over time in Sweden, in relation to the updated treatment recommendations.

methodsThis observational study is based on registry data. The study population consisted of patients ≥18 years old who, at any time between 2017 and 2023, had an HF diagnosis, defined using ICD-10 code I50 (n = 212,757). Descriptive statistics were presented for the study population. Based on data from the national drug prescription registry, the treatment patterns between 2021 and 2023 were analyzed using biannual datasets before and after the introduction of treatment recommendations.

resultsThe mean age of the study population was 79 years and 56% were men. The utilization of quadruple therapy and SGLT2 inhibitors, both as monotherapy and in combination, increased over time, with a rising trend already apparent prior to the introduction of the updated treatment recommendations. At the end of 2023, about 30% of the incident HF population had at least tried quadruple therapy. Furthermore, a growing number of diverse treatment pathways among HF patients was observed over time, which may indicate an increased consideration for individualized treatment.

conclusionsEven though the implementation of the treatment recommendations for HF is not yet optimal, this study found a notable adoption of quadruple therapy in Sweden. There was an increased use of SGLT2 inhibitors and quadruple therapy, beginning even before the introduction of the updated Swedish treatment recommendations.

Identifiers

PMID40372621
PMCPMC12173992

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