Evidence map›Paper›PMID 40372556›Full record

ArticleClinical and experimental medicine2025

Identification and functional characterization of hub genes CLTA, EDIL3, HAPLN1, and HIP1 as diagnostic biomarkers and therapeutic targets in thyroid cancer and Hashimoto's thyroiditis.

Tianyu Liu, Dechun Zhang, Wen Ouyang, Rongfang Li, Siying Wang, Weixuan Liu

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Article in Clinical and experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

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4citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Tianyu LiuDepartment of Geriatrics, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, 415000, China.
Dechun ZhangDepartment of Geriatrics, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, 415000, China.
Wen OuyangDepartment of Medical Affairs, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, 415000, China.
Rongfang LiDepartment of Geriatrics, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, 415000, China.
Siying WangDepartment of Geriatrics, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, 415000, China.
Weixuan LiuDepartment of Geriatrics, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, 415000, China. 13875107306@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we sought to identify key molecular players in both thyroid cancer (TC) and Hashimoto's thyroiditis (HT) by analyzing differentially expressed genes (DEGs) and their potential as biomarkers. We utilized datasets from the Gene Expression Omnibus (GEO) database and identified CLTA, EDIL3, HAPLN1, and HIP1 as hub genes common to both TC and HT. These genes were significantly upregulated in TC cell lines compared to normal controls, with high diagnostic accuracy as indicated by Receiver Operating Characteristic (ROC) curve analysis. Further validation using the TCGA TC dataset revealed their significant upregulation in tumor tissues, particularly in advanced TC stages. Promoter methylation analysis indicated hypomethylation of these genes in TC, suggesting a role of methylation in their regulation. We also observed mutations and copy number variations (CNVs) in these hub genes, with CLTA and HIP1 showing significant amplifications, which may contribute to their overexpression in tumor samples. In addition, we conducted a meta-analysis to assess the impact of these genes on survival outcomes in TC patients, with results indicating that higher expression of HAPLN1 and HIP1 was associated with poor survival. Our study also highlighted the involvement of CLTA and EDIL3 in activating the Rap1 signaling pathway, crucial for cancer cell migration, proliferation, and invasion. These findings emphasize the potential of CLTA, EDIL3, HAPLN1, and HIP1 as diagnostic biomarkers and therapeutic targets for TC and HT.

Indexed as

Biomarkers, TumorDNA-Binding ProteinsExtracellular Matrix ProteinsHashimoto DiseaseThyroid NeoplasmsCell Line, TumorDNA Copy Number VariationsDNA MethylationGene Expression ProfilingGene Expression Regulation, NeoplasticHumansBiomarkers, TumorDNA-Binding ProteinsExtracellular Matrix ProteinsHIP1 protein, humanBiomarkerHashimoto’s thyroiditisProliferationTherapeutic targetThyroid cancer

Identifiers

PMID40372556
PMCPMC12081531

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.