Excavation of acoustic nanostructures biosynthesis gene clusters by combinatorial strategy.

Wei Liu, Tingting Liu, Shenxi Huang, Fei Yan, Jian-Zhong Liu

Abstract read

In one paragraph

Article in Advanced biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Wei LiuState Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, 510275, People's Republic of China.

Tingting LiuDepartment of Ultrasound, The Second People's Hospital of Shenzhen, The First Affiliated Hospital of Shenzhen University, Shenzhen, 518061, China.

Shenxi HuangState Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, 510275, People's Republic of China.

Fei YanCAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China. fei.yan@siat.ac.cn.

Jian-Zhong LiuState Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, 510275, People's Republic of China. lssljz@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0002-1570-3214

Funding

National Key R&D Program of China 2020YFA0908800National Natural Science Foundation of China 32071422

6 · The paper itself

Abstract

Gas vesicles (GVs) produced by microorganisms are genetically engineered, air-filled protein nanostructures that have widespread applications in ultrasound imaging and ultrasound-mediated drug delivery. However, constrained by the shape and size, most of them are difficult to be imaged by clinical ultrasound machines, which limits their biomedical applications. Here, we constructed a hybrid gene cluster of the structural gene cluster from Serratia sp. ATCC 39006 and the accessory gene cluster from Bacillus megaterium in Escherichia coli to synthesize a novel gene-encoded gas vesicle with a width of approximately 70 nm and a length of about 100 nm, using a synthetic biology strategy, termed as ARG

Indexed as

Acoustic nanostructuresCombinatorial biosynthesis strategyEscherichia coliGas vesiclesSite-saturation mutagenesisUltrasound imaging

Identifiers

PMID40372536

DOI10.1007/s44307-025-00069-5

PMCPMC12081810

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.