Observational studyArchives of dermatological research2025
Role of serum interleukin-19 (IL-19) levels in acne vulgaris: a comprehensive case control study.
Observational study in Archives of dermatological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Assessment of Serum and Saliva CRP, IL-17, and IL-19 Levels in Patients with Different Severity of Acne Vulgaris.International journal of molecular sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acne vulgaris (AV) has a multifactorial pathogenesis, with inflammation being a key factor. The pro-inflammatory role of interleukin (IL)-19 has been explored in several systemic and some dermatological conditions. This study aimed to analyse serum levels of IL-19 in cases as well as healthy controls and to assess its correlation with the disease severity. A cross sectional, observational, analytical study was performed over a time period of 18 months at a tertiary care hospital. The study included 37 clinically diagnosed cases of acne aged between 16 to 30 years and 37 age and sex matched controls. Severity of the lesions was calculated using the Global Acne Grading System (GAGS). IL-19 levels of all the participants were measured with the help of quantitative Enzyme Linked Immunosorbent Assay (ELISA). The Spearman's rank correlation coefficient was used to evaluate the relationship between serum levels of IL-19 and the severity of AV, and a p-value of less than 0.05 was considered statistically significant. In this study, serum IL-19 levels showed a positive correlation with both the patients' age and the duration of their symptoms, with p values of 0.04 for each. The median serum IL-19 levels were observed to be higher in the cases (80.89 ng//L) as compared to controls (44.82 ng/L), although this difference was not statistically significant (p = 0.095). Additionally, no significant correlation was found between IL-19 levels and the severity of acne (p = 0.45). Unlike prior work, our study found no link between IL-19 and severity of AV. Thus, we conclude that IL-19 may not be a reliable marker of the disease severity as previously stated and further research, preferably in larger sample size is warranted to confirm the same.
Indexed as
Identifiers
40372535What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.