ArticleJournal of gastrointestinal cancer2025
Patterns of Lymph Node Recurrence after Esophagectomy of pT2-3 N0M0 Esophageal Squamous Cell Carcinoma.
Article in Journal of gastrointestinal cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThis study aims to elucidate the distribution patterns of lymph node recurrence (LNR) in patients with pT2-3N0M0 esophageal squamous cell carcinoma (ESCC) following esophagectomy.
methodsA comprehensive retrospective analysis was conducted on 96 pT2-3N0M0 ESCC patients who experienced postoperative LNR at our institution between January 2010 and August 2019. LNR sites were systematically categorized into cervical, mediastinal, and abdominal regions. Computed tomography imaging was digitally reconstructed to precisely map recurrence locations, followed by rigorous statistical analysis of distribution patterns.
resultsThe final cohort comprised 96 patients with confirmed LNR, with males constituting 79.2% of the sample and a median age of 61 years. Mediastinal LNR was determined to be the most prevalent (69.8%), followed by cervical (43.8%) and abdominal (33.3%) regions. Cervical recurrences were predominantly identified in lymph node station 104R/L (7.8%), while mediastinal recurrences were predominantly localized to station 106recR (14.5%) and station 105 (10.4%), and abdominal recurrences were concentrated in stations 16a2 (3.6%) and 9 (3.6%). Computerized tomography reconstruction demonstrated a distinctive "T"-shaped distribution of LNR in the cervical and upper mediastinal regions in proximity to major vascular structures. The primary tumor location was not found to significantly influence LNR distribution patterns (P > 0.05).
conclusionsLNR in pT2-3N0M0 ESCC predominantly manifests in cervical and upper mediastinal lymph nodes. Administering targeted adjuvant radiotherapy to high-risk patients may be an effective strategy for enhancing therapeutic outcomes. Prospective multicenter studies are warranted to validate these preliminary findings.
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