Evidence map›Paper›PMID 40372499›Full record

SynthesisClinical and experimental medicine2025

Bidirectional association between uveitis and psoriasis: a systematic review and meta-analysis.

Doudou Wu, Rui Cai, Ying Pang, Jie Ma, Bailin Chen, Siran Bao, Kaili Zheng, Wenbo Jiang, Yiming Qi, Nuo Li

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical and experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Doudou WuDepartment of Integrative Traditional Chinese and Western Medicine, Beijing University of Chinese Medicine, Beijing, China.
Rui CaiDepartment of Integrative Traditional Chinese and Western Medicine, Beijing University of Chinese Medicine, Beijing, China.
Ying PangDepartment of Chinese Medicine, Beijing Nuclear Industry Hospital, Beijing, China.
Jie MaDepartment of Dermatology, National Center for Integrated Traditional Chinese and Western Medicine, China-Japan Friendship Hospital, Beijing, China.
Bailin ChenDepartment of Integrative Traditional Chinese and Western Medicine, Beijing University of Chinese Medicine, Beijing, China.
Siran BaoDepartment of Integrative Traditional Chinese and Western Medicine, Beijing University of Chinese Medicine, Beijing, China.
Kaili ZhengDepartment of Integrative Traditional Chinese and Western Medicine, Beijing University of Chinese Medicine, Beijing, China.
Wenbo JiangDepartment of Integrative Traditional Chinese and Western Medicine, Beijing University of Chinese Medicine, Beijing, China.
Yiming QiDepartment of Integrative Traditional Chinese and Western Medicine, Beijing University of Chinese Medicine, Beijing, China.
Nuo LiDepartment of Dermatology, National Center for Integrated Traditional Chinese and Western Medicine, China-Japan Friendship Hospital, Beijing, China. nola8316@sina.com.

Funding

National Natural Science Foundation of China Young Scientist Fund 8220141727Natural Science Foundation of Beijing Municipality 7232318
6 · The paper itself

Abstract

backgroundIn recent years, the prevalence of uveitis among patients with psoriasis has shown a noticeable upward trend. Previous studies have investigated the immunological mechanisms underlying the potential connection between psoriasis and uveitis, but systematic studies exploring their bidirectional relationship is absent. This study aims to systematically evaluate the bidirectional association between psoriasis and uveitis to provide evidence.

methodsWe thoroughly searched PubMed, Embase, and the Cochrane Library for relevant observational studies published from the inception of these databases up to Mar 11th, 2024. Our systematic review was based on priori protocol pre-registered in PROSPERO (No. CRD42024522464). Risk and bias assessments were analyzed using STATA 16.0.

resultsWe analyzed the results from 7 studies involving 81,775,820 subjects. The results showed that the incidence of uveitis was higher in patients with psoriasis compared to patients without psoriasis (OR = 1.16, 95% CI: 1.11-1.21). At the same time, patients with uveitis showed heightened susceptibility to psoriasis (OR = 1.52, 95% CI: 1.34-1.70, I

conclusionsThe current systematic review and meta-analysis found a bidirectional association between psoriasis and uveitis. Notably, patients with severe psoriasis and psoriasis with joint symptoms should be informed about their increased risk to developing uveitis.

Indexed as

PsoriasisUveitisHumansIncidencePrevalenceImmunologyInflammatory diseaseMeta-analysisPsoriasisUveitis

Identifiers

PMID40372499
PMCPMC12081564

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.