Evidence map›Paper›PMID 40372490›Full record

ArticleNeurosurgical review2025

Upfront frameless hypofractionated gamma knife radiosurgery for large posterior Fossa metastases.

Yavuz Samanci, Serhat Aydin, Ali Haluk Düzkalir, M Orbay Askeroglu, Selcuk Peker

Abstract read
In one paragraph

Article in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yavuz SamanciDepartment of Neurosurgery, Koç University School of Medicine, Türkiye Davutpasa Caddesi No:4, Zeytinburnu/İstanbul, 34010, Türkiye.ORCID http://orcid.org/0000-0001-8952-6866
Serhat AydinKoç University School of Medicine, Istanbul, Türkiye.ORCID http://orcid.org/0000-0003-3672-7626
Ali Haluk DüzkalirDepartment of Neurosurgery, Gamma Knife Center, Koç University Hospital, Istanbul, Türkiye.ORCID http://orcid.org/0000-0002-2535-9832
M Orbay AskerogluDepartment of Neurosurgery, Gamma Knife Center, Koç University Hospital, Istanbul, Türkiye.ORCID http://orcid.org/0000-0001-7126-6373
Selcuk PekerDepartment of Neurosurgery, Koç University School of Medicine, Türkiye Davutpasa Caddesi No:4, Zeytinburnu/İstanbul, 34010, Türkiye. peker@selcukpeker.com.ORCID http://orcid.org/0000-0003-3057-3355

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The management of large metastatic brain tumors (METs), particularly those in the posterior fossa (pf-METs), is challenging. While surgery can alleviate symptoms, it carries the risk of complications such as leptomeningeal disease (LMD). Upfront hypofractionated Gamma Knife radiosurgery (hf-GKRS) has shown promise as an alternative approach for managing large METs. This study assesses the efficacy and safety of upfront hf-GKRS for treatment-naïve large pf-METs. In this retrospective, single-center study, 40 patients with 42 pf-METs received hf-GKRS from October 2017 to June 2024. Patients eligible for the study were 18 years or older, had histologically confirmed malignancy, large pf-METs (> 4 cm

Indexed as

Brain NeoplasmsInfratentorial NeoplasmsRadiosurgeryAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedRadiation Dose HypofractionationRetrospective StudiesTreatment OutcomeGamma knife radiosurgeryHypofractionationMetastatic brain tumorsPosterior fossaUpfront radiosurgery

Identifiers

PMID40372490
PMCPMC12081571

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.