Evidence map›Paper›PMID 40372475›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2025

The m6 A modification of CDKN2 A inhibites ferroptosis and affects the resistance of cervical squamous cell carcinoma to cisplatin.

Xiang Yong, Xifeng Xu, Xiaoping Zhang, Rui Song, Huaiyuan Hu, Zhen Li, Yanzi Qin

Abstract read
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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. RNA modifications and cancer ferroptosis.Cancer cell international · 2026
    Review
  2. Article
  3. Frontiers in genetics · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiang YongDepartment of Pathology, Wanbei Coal-Electricity Group General Hospital, No. 125, Huaihe West Road, Suzhou City, 234000, Anhui Province, China.
Xifeng XuDepartment of Pathology, Bengbu Medical University, No. 2600, Donghai Avenue, Bengbu City, Anhui Province, China.
Xiaoping ZhangDepartment of Pathology, Bengbu Medical University, No. 2600, Donghai Avenue, Bengbu City, Anhui Province, China.
Rui SongDepartment of Pathology, Wanbei Coal-Electricity Group General Hospital, No. 125, Huaihe West Road, Suzhou City, 234000, Anhui Province, China.
Huaiyuan HuDepartment of Pathology, Wanbei Coal-Electricity Group General Hospital, No. 125, Huaihe West Road, Suzhou City, 234000, Anhui Province, China. huaiyuan_Hu_hhy@163.com.
Zhen LiDepartment of Pathology, The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University/The First Hospital of Changsha, No. 311, Yingpan Road, Kaifu District, Changsha City, 410000, Hunan Province, China. Li_zhen_701@163.com.
Yanzi QinDepartment of Pathology, Bengbu Medical University, No. 2600, Donghai Avenue, Bengbu City, Anhui Province, China. Qin_Yanzi_qyz@163.com.

Funding

Research Project of the Health Commission of Hunan Province No. 202201042974Science and Technology Innovation Program of Hunan Province No. 2021SK53102Science Foundation of Changsha Science and Technology Project No. kq2004157
6 · The paper itself

Abstract

Cervical squamous cell carcinoma (CESC) is the fourth most common malignancy and the fourth leading cause of cancer deaths in women worldwide. Despite advances in treatment, cisplatin-based radiotherapy remains the primary treatment option. However, cisplatin resistance is a major challenge, leading to poor prognosis. Therefore, understanding the molecular mechanisms underlying cisplatin resistance is crucial for developing novel therapeutic strategies. Through bioinformatics analysis, we investigated the expression of CDKN2A in the CESC database. WB, IHC, qPCR, and CCK-8 were used for clinical analysis of CDKN2A expression and its correlation with CESC cell proliferation. Through qPCR, CCK-8, ROS, MDA, Fe

Indexed as

Antineoplastic AgentsCarcinoma, Squamous CellCisplatinCyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor p18Drug Resistance, NeoplasmFerroptosisUterine Cervical NeoplasmsAdenosineAnimalsCell Line, TumorCell ProliferationFemaleHumansMethyltransferasesMiceAdenosineAntineoplastic AgentsCDKN2A protein, humanCisplatinCyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor p18MethyltransferasesMETTL3 protein, humanN-methyladenosineCDKN2 ACESCCisplatinFerroptosisM6 A RNA methylation

Identifiers

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.