Evidence map›Paper›PMID 40372467›Full record

ArticleWorld journal of urology2025

Platelet-rich plasma intra-plaque injections rapidly reduce penile curvature and improve sexual function in Peyronie's disease patients: results from a prospective large-cohort study.

Giuseppe Dachille, Andrea Panunzio, Leonardo Bizzotto, Maria Valeria D'Agostino, Federico Greco, Giuseppe Guglielmi, Umberto Carbonara, Marco Spilotros, Claudia Citarella, Angelo Ostuni and 4 more

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Article in World journal of urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Giuseppe Dachille *Department of Precision and Regenerative Medicine and Ionian Area Urology, Andrology and Kidney Transplantation Unit, University of Bari, Bari, Italy. gdachille@hotmail.com.
Andrea Panunzio *Department of Urology, "Vito Fazzi" Hospital, Lecce, Italy.
Leonardo BizzottoPolicologna Medical Center, Cologna Veneta, Verona, Italy.
Maria Valeria D'AgostinoDepartment of Precision and Regenerative Medicine and Ionian Area Urology, Andrology and Kidney Transplantation Unit, University of Bari, Bari, Italy.
Federico GrecoDepartment of Radiology, Cittadella Della Salute, Azienda Sanitaria Locale Di Lecce, Lecce, Italy.
Giuseppe GuglielmiDepartment of Precision and Regenerative Medicine and Ionian Area Urology, Andrology and Kidney Transplantation Unit, University of Bari, Bari, Italy.
Umberto CarbonaraDepartment of Precision and Regenerative Medicine and Ionian Area Urology, Andrology and Kidney Transplantation Unit, University of Bari, Bari, Italy.
Marco SpilotrosDepartment of Precision and Regenerative Medicine and Ionian Area Urology, Andrology and Kidney Transplantation Unit, University of Bari, Bari, Italy.
Claudia CitarellaTransfusion Medicine Unit, Policlinico University Hospital, Bari, Italy.
Angelo OstuniTransfusion Medicine Unit, Policlinico University Hospital, Bari, Italy.
Giuseppe LucarelliDepartment of Precision and Regenerative Medicine and Ionian Area Urology, Andrology and Kidney Transplantation Unit, University of Bari, Bari, Italy.
Pasquale DitonnoDepartment of Precision and Regenerative Medicine and Ionian Area Urology, Andrology and Kidney Transplantation Unit, University of Bari, Bari, Italy.
Alessandro TafuriDepartment of Urology, "Vito Fazzi" Hospital, Lecce, Italy.
REACT (Research in Exploring Andrology, Cutting-edge Technologies) group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate efficacy and safety of platelet-rich plasma (PRP) intra-plaque injections in Peyronie's disease (PD) patients.

methodsThree injections of 6 mL PRP were performed two weeks apart. Patients were evaluated at baseline (T0, first injection), after two weeks (T1, second injection), and four weeks after the third injection (T2). The curvature angle of the erect penis, plaque size, dedicated sexual function questionnaires (PD questionnaire-PDQ, and International Index of Erectile Function five-items - IIEF-5) scores, and adverse events/side effects were evaluated.

resultsOverall, 72 patients were included. Median age was 60 years, and median BMI was 23.1 kg/m

conclusionPRP is a safe and effective treatment option in men with PD, rapidly reducing plaques size and penile curvature angle, thus positively influencing sexual function. The higher the BMI the lower benefit might be derived from PRP injection.

Indexed as

Erectile DysfunctionPenile ErectionPenile IndurationPenisPlatelet-Rich PlasmaAdultAgedCohort StudiesHumansInjectionsInjections, IntralesionalMaleMiddle AgedProspective StudiesTreatment OutcomeBody mass indexPenile curvaturePenile indurationPeyronie’s diseasePlatelet rich plasmaRegenerative medicine

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.