[Empirical antibiotic therapy in life-threatening infections-current concepts and controversies].

A Brinkmann, U Chiriac, C Eckmann, O R Frey, B Grabein, S Hagel, D Richter, U Liebchen

Abstract readCase ReportsEnglish Abstract

In one paragraph

Article in Die Anaesthesiologie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

A BrinkmannKlinik für Anästhesie, operative Intensivmedizin und spezielle Schmerztherapie, Klinikum Heidenheim, Schlosshaustraße 100, 89522, Heidenheim, Deutschland. Alexander.Brinkmann@kliniken-heidenheim.de.

U ChiriacApotheke, Universitätsklinikum Heidelberg, Heidelberg, Deutschland.

C EckmannKlinik für Allgemein‑, Viszeral- und Thoraxchirurgie und ABS-Team, Klinikum Hannoversch-Münden, Universitätsmedizin Göttingen, Hannoversch-Münden, Deutschland.

O R FreyApotheke, Kliniken Landkreis Heidenheim, Heidenheim, Deutschland.

B GrabeinStabsstelle Klinische Mikrobiologie und Krankenhaushygiene, LMU Klinikum, LMU München, München, Deutschland.

S HagelInstitut für Infektionsmedizin und Krankenhaushygiene, Universitätsklinikum Jena, Jena, Deutschland.

D RichterKlinik für Anästhesiologie, Universitätsklinikum Heidelberg, Heidelberg, Deutschland.

U LiebchenKlinik für Anaesthesiologie, LMU Klinikum, LMU München, München, Deutschland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Along with early administration and the selection of the right drug, it is important to consider pharmacokinetic and pharmacodynamic principles, especially in life-threatening infections. Therefore, successful antibiotic therapy requires a clear understanding of the relationship between microbiology, pharmacology, and intensive care medicine. Open and transparent communication among professionals is essential for improving the quality of care. This article discusses current concepts and controversies by presenting a relevant case study of community-acquired pneumonia. It aims to help clinicians select the right drug for each patient, including the correct dose, the appropriate administration, and the right duration of treatment.

Indexed as

Anti-Bacterial AgentsCommunity-Acquired InfectionsCritical CareHumansAnti-Bacterial AgentsAntibiotic therapyDosing toolsPharmacokinetics and pharmacodynamicsSepsisTherapy duration

Identifiers

PMID40372450

DOI10.1007/s00101-025-01531-8

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.