Evidence map›Paper›PMID 40372430›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

UTX (KDM6A) promotes differentiation noncatalytically in somatic self-renewing epithelia.

Gina N Pacella, Nina Kuprasertkul, Lydia Bao, Sijia Huang, Carina D'souza, Stephen M Prouty, Amy Anderson, Alexandra M Maldonado López, Morgan Sinkfield, Cyria Olingou and 2 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Gina N PacellaDepartment of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.ORCID 0000-0002-0149-9312
Nina KuprasertkulDepartment of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.
Lydia BaoDepartment of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.
Sijia HuangPenn Institute of Biomedical Informatics, University of Pennsylvania, Perelman School of Medicine, Philadelphia PA 19104.
Carina D'souzaDepartment of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.
Stephen M ProutyDepartment of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.ORCID 0000-0001-9436-8268
Amy AndersonDepartment of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.
Alexandra M Maldonado LópezDepartment of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.
Morgan SinkfieldDepartment of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.ORCID 0009-0002-1219-4714
Cyria OlingouDepartment of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.
John T SeykoraDepartment of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.ORCID 0000-0003-0383-031X
Brian C CapellDepartment of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.ORCID 0000-0002-7036-8359

Funding

Study Design and Data AnalysisP30AR069589 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth Anne Grice · 2016 to 2026
$8.6M
Epigenetic enhancer control in maintaining homeostasis and preventing carcinogenesis in the epidermisR01AR077615 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI CAPELL, BRIAN · 2020 to 2024
$2.1M
Epigenomic mechanisms of skin carcinogenesisK08AR070289 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI CAPELL, BRIAN · 2016 to 2020
$698k
Damon Runyon Cancer Research Foundation (DRCRF) Clinical Investigator AwardDermatology Foundation (DF) Stiefel AwardHHS | NIH | National Cancer Institute (NCI) CA2653233HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) K08AR070289HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) R01AR077615NIAMS NIH HHS K08 AR070289NIAMS NIH HHS P30 AR069589NIAMS NIH HHS R01 AR077615
6 · The paper itself

Abstract

The X-linked histone demethylase, UTX (

Indexed as

Cell DifferentiationHistone DemethylasesAnimalsFemaleMaleMiceMice, KnockoutSignal TransductionTretinoinHistone DemethylasesTretinoinUtx protein, mousedifferentiationepigeneticsretinoid signalingsex biasskin biology

Identifiers

PMID40372430
PMCPMC12107135

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.