Evidence map›Paper›PMID 40372166›Full record

ArticleThe Kaohsiung journal of medical sciences2025

LRP8 Regulates Lipid Metabolism to Stimulate Malignant Progression and Cisplatin Resistance in Bladder Cancer.

Gang-Feng Wu, Zhen-Gang Luo, Ke Gao, Yu Ren, Chong Shen, Xiang-Rong Ying

Abstract read
In one paragraph

Article in The Kaohsiung journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Targeted extracellular degradation of LRP8 promotes ferroptosis in cancer cells.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gang-Feng WuDepartment of Urology, Shaoxing People's Hospital, Shaoxing, China.
Zhen-Gang LuoDepartment of Urology, Shaoxing People's Hospital, Shaoxing, China.
Ke GaoDepartment of Urology, Shaoxing People's Hospital, Shaoxing, China.
Yu RenDepartment of Urology, Shaoxing People's Hospital, Shaoxing, China.
Chong ShenDepartment of Urology, Shaoxing People's Hospital, Shaoxing, China.
Xiang-Rong YingDepartment of Urology, Shaoxing People's Hospital, Shaoxing, China.ORCID https://orcid.org/0000-0003-1992-5620

Funding

2024 Health Science and Technology Project of Zhejiang Province 2024KY1719
6 · The paper itself

Abstract

Low-density lipoprotein receptor-related protein 8 (LRP8) is a crucial regulator of lipid metabolism and is implicated in the development and treatment of various cancers. However, its role in bladder cancer (BCa) remains unknown. We analyzed LRP8 expression in BCa using the TCGA database and clinical samples. We manipulated LRP8 expression in tumor cell lines using siRNA or overexpression plasmid transfection. Cell proliferation, migration, invasion, apoptosis, and drug resistance were assessed through CCK-8, transwell, flow cytometry, and IC

Indexed as

CisplatinDrug Resistance, NeoplasmLipid MetabolismUrinary Bladder NeoplasmsApoptosisCell Line, TumorCell MovementCell ProliferationDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansMaleCisplatinbladder cancercisplatin resistancelipid metabolismLRP8

Identifiers

PMID40372166
PMCPMC12412626

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.