ArticleJournal of magnetic resonance imaging : JMRI2025
Repeatability of Magnetic Resonance Elastography-Derived Mechanical Parameters in Intracranial Meningiomas.
Article in Journal of magnetic resonance imaging : JMRI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Mechanical instability as a signature of viscoelastic decoupling at the tumor-brain interface.Biomaterials advances · 2026Article
- Elasticity-guided tumor resection: applying biomechanical information to neurosurgical practice.Acta neurochirurgica · 2026Review
- Mechanical Instability as a Signature of Viscoelastic Decoupling at the Tumor-Brain Interface.medRxiv : the preprint server for health sciences · 2025Article
- Repeatability of Magnetic Resonance Elastography-Derived Mechanical Parameters in Intracranial Meningiomas.Journal of magnetic resonance imaging : JMRI · 2025Article
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10 authors.
Funding
Abstract
backgroundMagnetic resonance elastography (MRE) quantifies tissue viscoelasticity, offering insights into intracranial meningiomas. MRE-derived parameters, including the storage modulus (G') and the magnitude of the complex modulus (|G*|), may aid neurosurgical planning, but their repeatability remains unexplored in brain tumors. PURPOSE/HYPOTHESIS: To evaluate the repeatability of G' and |G*| in meningiomas, the influence of tumor volume and spatial location on variability, and ranking stability across paired elastograms. STUDY TYPE: Prospective. POPULATION/SUBJECTS: Seventeen paired MRE scans from 16 patients with meningiomas (mean age 64 ± 12 years, 10 females) scheduled for resection. FIELD STRENGTH/SEQUENCE: MRE was performed on a 3 T system using a single-shot spin-echo echo-planar imaging (SE-EPI) sequence. ASSESSMENT: Tumors were segmented on contrast-enhanced T1-weighted images; distance and volume metrics were extracted. Regions of interest were applied to G' and |G*| elastograms. Repeatability was evaluated using the coefficient of variation (CV%). Ranking stability was assessed by comparing median G' or |G*| values. STATISTICAL TESTS: The difference in CV% was assessed using the Wilcoxon signed rank test. Linear regression assessed the effect of tumor volume and distance from the external occipital protuberance (EOP) on CV%. The Wilcoxon signed-rank test evaluated ranking stability and scan-rescan CV%. Statistical significance was defined as p < 0.05.
resultsThe difference in CV% G' (14.89 ± 12.32) and CV% |G*| (13.88 ± 12.60) was not significant (p = 0.61). Tumor volume inversely correlated with CV% (G': β = -0.75 |G*|: β = -0.59). Tumor-EOP distance had no significant effect (G': p = 0.58, |G*|: p = 0.23). Rankings remained stable (G': p = 0.82, |G*|: p = 0.71). DATA
conclusionMRE-derived parameters are repeatable in intracranial meningiomas, with G' and |G*| being equally stable. Larger tumors yielded more consistent estimates. Preserved ranking stability supports the use of MRE in preoperative planning. EVIDENCE LEVEL: 2. TECHNICAL EFFICACY: Stage 2.
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