Evidence map›Paper›PMID 40372028›Full record

ArticleAIDS (London, England)2025

Adverse childhood experiences, sexual orientation-related victimization, and cardiovascular disease risk among men with and without HIV.

Allison A Appleton, Serim Lee, Mark H Kuniholm, Elizabeth Vásquez, Mardge H Cohen, Jessica Donohue, Michelle Floris-Moore, M Reuel Friedman, Deborah Gustafson, David B Hanna and 8 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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5 · Who and what money

Authors and funding

18 authors.

Allison A AppletonDepartment of Epidemiology and Biostatistics, University at Albany, State University of New York, Rensselaer, NY.
Serim LeeDepartment of Epidemiology and Biostatistics, University at Albany, State University of New York, Rensselaer, NY.
Mark H KuniholmDepartment of Epidemiology and Biostatistics, University at Albany, State University of New York, Rensselaer, NY.
Elizabeth VásquezDepartment of Epidemiology and Biostatistics, University at Albany, State University of New York, Rensselaer, NY.
Mardge H CohenDepartment of Medicine, Stroger Hospital of Cook County, Chicago, IL.
Jessica DonohueJohns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Michelle Floris-MooreDepartment of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC.
M Reuel FriedmanDepartment of Urban-Global Public Health, School of Public Health, Rutgers University, New Brunswick, NJ.
Deborah GustafsonDepartment of Neurology, State University of New York Downstate Health Sciences University, Brooklyn.
David B HannaDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY.
Deborah L JonesDepartment of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL.
Matthew J MimiagaDepartment of Epidemiology, University of California Los Angeles Fielding School of Public Health, Los Angeles, CA.
Caitlin A MoranDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA.
Michael W PlankeyDepartment of Medicine, Division of General Internal Medicine, Georgetown University Medical Center, Washington, DC.
Sanyog G ShitoleCardiology Section, San Francisco Veterans Affairs Healthcare System, San Francisco, CA.
Linda A TeplinDepartment of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL.
Deanna WareDepartment of Medicine, Division of General Internal Medicine, Georgetown University Medical Center, Washington, DC.
Jenni M WiseDepartment of Family, Community, and Health Systems, School of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA.

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul A. Goepfert · 1988 to 2026
$84.1M
Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0M
QAQC Johns Hopkins Institute for Clinical and Translational ResearchUL1TR003098 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2019 to 2023
$57.7M
Maternal Morbidity and Mortality: Risk Factors, Early Detection and Personalized InterventionUL1TR001409 · NCATS · GEORGETOWN UNIVERSITY · PI GONDRE-LEWIS, MARJORIE C, MELLMAN, THOMAS A · 2015 to 2024
$37.8M
SF Bay Area MACS/WIHS Combined Cohort StudyU01HL146242 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Bradley E Aouizerat, Jennifer Cohen Price · 2019 to 2026
$36.3M
Sex differences in the role of multi-omicsin HIV-associated carotid artery atherosclerosisU01HL146193 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Stephen J Gange, Elizabeth Topper · 2019 to 2026
$35.8M
University of Miami Developmental Center for AIDS Research (D-CFAR)P30AI073961 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Savita Pahwa · 2007 to 2026
$33.8M
Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center - Admin Supplement: Vision and dual sensory loss in HIV-infected older adultsU01HL146201 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TODD T BROWN, Joseph B. Margolick · 2019 to 2026
$33.7M
Sex differences in the role of multi-omics in HIV-associated carotid artery atherosclerosisU01HL146204 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI David B. Hanna, Anjali Sharma · 2019 to 2026
$33.2M
NCATS NIH HHS KL2 TR001432NCATS NIH HHS TL1 TR001431NCATS NIH HHS UL1 TR000004NCATS NIH HHS UL1 TR001409NCATS NIH HHS UL1 TR001881NCATS NIH HHS UL1 TR003098NHLBI NIH HHS U01 HL146192NHLBI NIH HHS U01 HL146193NHLBI NIH HHS U01 HL146194NHLBI NIH HHS U01 HL146201NHLBI NIH HHS U01 HL146202NHLBI NIH HHS U01 HL146203NHLBI NIH HHS U01 HL146204NHLBI NIH HHS U01 HL146205NHLBI NIH HHS U01 HL146208NHLBI NIH HHS U01 HL146240NHLBI NIH HHS U01 HL146241NHLBI NIH HHS U01 HL146242NHLBI NIH HHS U01 HL146245NHLBI NIH HHS U01 HL146333NIAID NIH HHS P30 AI027767NIAID NIH HHS P30 AI050409NIAID NIH HHS P30 AI050410NIAID NIH HHS P30 AI073961NIMH NIH HHS P30 MH116867
6 · The paper itself

Abstract

objectiveAdverse childhood experiences (ACEs) are traumatic events occurring before age 18 and can increase cardiovascular disease (CVD) risk. Many sexual minority men (SMM) and men with HIV (MWH) have trauma histories and elevated CVD risk. We investigated the association between ACEs and CVD risk among SMM with and without HIV (MWH and MWOH). DESIGN AND

methodsData were from the Multicenter AIDS Cohort Study ( n  = 1245; n  = 650 MWOH, n  = 595 MWH). Participants self-reported 20 ACEs reflecting household dysfunction and victimization. CVD risk was measured with Framingham (FRS-H) and American College of Cardiology/American Heart Association-Pooled Cohort Equation (ACC/AHA-PCE) scores. Longitudinal generalized estimating equations (GEE) using 10 years of repeated CVD measures were examined with each ACE type, total number of ACEs, and ACE latent classes.

resultsThe prevalence of each ACE was high, ranging from 50.3 to 83.8%. Childhood sexual orientation-related victimization was positively associated with CVD risk for MWOH ( βFRS-H  = 2.95, SE = 1.48, P  = 0.005; βACC/AHA-PCE  = 3.31, SE = 1.48, P  = 0.002) and MWH ( βFRS-H  = 2.69, SE = 1.58, P  = 0.03; βACC/AHA-PCE  = 2.82, SE = 1.62, P  = 0.03). Among MWH, ACE Class 2 (characterized by high sexual orientation-related victimization, moderate levels of parental abuse, and household dysfunction) was associated with higher CVD risk ( βFRS-H  = 3.63, SE = 1.78, P  = 0.03; βACC/AHA-PCE  = 3.09, SE = 1.78, P  = 0.05). Dose-response associations were observed for the full sample when considering the total number of ACEs, though attenuated in models stratified by HIV status.

conclusionACEs were associated with CVD risk among MWH and MWOH. Assessing ACE history in clinical encounters may yield important insights for the prevention and management of CVD. This study underscores the importance of trauma-informed care for this population.

Indexed as

Adverse Childhood ExperiencesCardiovascular DiseasesCrime VictimsHIV InfectionsSexual and Gender MinoritiesSexual BehaviorAdultChildCohort StudiesHumansLongitudinal StudiesMaleMiddle AgedPrevalenceRisk AssessmentRisk Factorsadverse childhood experiencescardiovascular diseasesexual orientation-related victimization

Identifiers

PMID40372028
PMCPMC12324952

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