Evidence map›Paper›PMID 40372025›Full record

ArticleAntimicrobial agents and chemotherapy2025

Individual target pharmacokinetic/pharmacodynamic attainment rates among cefepime-treated patients admitted to the ICU with hospital-acquired pneumonia with and without ECMO.

Adrian Valadez, Marta Zurawska, Emma Harlan, Marc H Scheetz, MIchael N Neely, Paul R Yarnold, Mengjia Kang, Erin Korth, Francisco Martinez, Bridget Giblin and 10 more

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Adrian ValadezDepartment of Pharmacy Practice, College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA.ORCID 0009-0003-4192-5229
Marta ZurawskaDepartment of Pharmacy Practice, College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA.
Emma HarlanDepartment of Pharmacy Practice, College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA.
Marc H ScheetzDepartment of Pharmacy Practice, College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA.ORCID 0000-0002-1091-6130
MIchael N NeelyKeck School of Medicine, University of Southern California, Los Angeles, California, USA.
Paul R YarnoldOptimal Data Analysis, LLC, Chicago, Illinois, USA.
Mengjia KangDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Erin KorthDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Francisco MartinezDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Bridget GiblinDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Helen K DonnellyDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Kay DedicatoriaDepartment of Pharmacy Practice, College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA.
Rachel MedernachDivision of Infectious Diseases, Department of Internal Medicine, RUSH University Medical Center, Chicago, Illinois, USA.
Sophia NozickDepartment of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Alan R HauserDepartment of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID 0000-0003-4596-7939
Egon A OzerDivision of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID 0000-0002-7131-3691
Estefani DiazRobert H. Lurie Comprehensive Cancer Research Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Alexander V MisharinDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Richard G WunderinkDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID 0000-0002-8527-4195
Nathaniel J RhodesDepartment of Pharmacy Practice, College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA.ORCID 0000-0002-0018-5434

Funding

Tissue resident macrophages regulate proteostasis in the aging lungP01AG049665 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI NAVDEEP S CHANDEL · 2015 to 2026
$26.9M
Technology CoreU19AI135964 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LUIS A. Nunes AMARAL · 2018 to 2026
$24.7M
The Cell Phenotyping and Mouse CoreP01HL154998 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KAREN M RIDGE · 2021 to 2026
$18.9M
CRITICAL: Collaborative Resource for Intensive care Translational science, Informatics, Comprehensive Analytics, and LearningU01TR003528 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CIMINO, JAMES J, LUO, YUAN · 2021 to 2024
$4.9M
Mechanisms of regulatory T cell-mediated recovery from severe viral pneumoniaR01HL149883 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Benjamin David Singer · 2020 to 2026
$4.1M
Systems-based pharmacologic modelling to elucidate beta-lactam clinical pharmacodynamics and define optimal dosing regimens in severe pneumoniaR01AI158530 · NIAID · MIDWESTERN UNIVERSITY · PI Nathaniel James Rhodes · 2022 to 2026
$3.4M
Lung transplant injury drives chronic lung allograft dysfunction via recruitment ofmonocyte-derived alveolar macrophagesR01HL153312 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MISHARIN, ALEXANDER · 2020 to 2023
$2.9M
Targeting abnormal alveolar immune activation and failed epithelial repair in COVID-19R01HL158139 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BUDINGER, GR SCOTT, MISHARIN, ALEXANDER · 2022 to 2025
$2.9M
Translational Research Training in Infectious DiseasesT32AI095207 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Claudia A Hawkins, Jennie H Kwon · 2012 to 2026
$2.2M
Modeling the Incompleteness and Biases of Health DataR01LM013337 · NLM · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LUO, YUAN · 2020 to 2023
$1.3M
Microglia mediate cognitive dysfunction in elderly survivors of pneumoniaR21AG075423 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BUDINGER, GR SCOTT, MISHARIN, ALEXANDER · 2022 to 2022
$440k
Midwestern UniversityNational Institute of Allergy and Infectious Diseases R01AI158530National Institute of Allergy and Infectious Diseases U19AI135964National Institute of Allergy and Infectious Diseases U19AI135964,T32AI095207NCATS NIH HHS U01 TR003528NHLBI NIH HHS P01 HL154998NHLBI NIH HHS R01 HL149883NHLBI NIH HHS R01 HL153312NHLBI NIH HHS R01 HL158139NIAID NIH HHS L30 AI178765NIAID NIH HHS R01 AI158530NIAID NIH HHS T32 AI095207NIAID NIH HHS U19 AI135964NIA NIH HHS P01 AG049665NIA NIH HHS R21 AG075423NIH HHS U19AI135964, P01AG049665, R21AG075423, R01HL158139, R01HL153312, P01HL154998NIH HHS U19AI135964, U01TR003528, P01HL154998, R01HL149883, R01LM013337, R01AI158530NLM NIH HHS R01 LM013337
6 · The paper itself

Abstract

Cefepime (FEP) is used for hospital- and ventilator-associated pneumonia when

Indexed as

Anti-Bacterial AgentsCefepimeCephalosporinsExtracorporeal Membrane OxygenationHealthcare-Associated PneumoniaAdultAgedBayes TheoremFemaleHumansIntensive Care UnitsMaleMicrobial Sensitivity TestsMiddle AgedMonte Carlo MethodProspective StudiesAnti-Bacterial AgentsCefepimeCephalosporinspharmacokinetics extracorporeal membrane oxygenation

Identifiers

PMID40372025
PMCPMC12135513

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.