Evidence map›Paper›PMID 40371917›Full record

ArticleAnalytical chemistry2025

An Efficient Electrochemiluminescence Biosensor Based on Ru(bpy)

Kexing Peng, Shuang Xu, Mimi Li, Yue Hu, Tianfeng Luo, Xiaocheng Liu, Chenghong Li, Yang Xiang, Hui Huang, Lina Wang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kexing PengEmergency Department, Second Affiliated Hospital of Chongqing Medical University, 400010 Chongqing, China.
Shuang XuDepartment of Clinical and Military Laboratory Medicine, College of Pharmacy and Laboratory Medicine, Army Medical University, No. 30 Gaotanyan Street, Shapingba District, 400038 Chongqing, China.
Mimi LiEmergency Department, Second Affiliated Hospital of Chongqing Medical University, 400010 Chongqing, China.
Yue HuEmergency Department, Second Affiliated Hospital of Chongqing Medical University, 400010 Chongqing, China.
Tianfeng LuoWanzhou Shanghai Hospital, Chongqing, No. 112 Shanghai Street, Wanzhou District, 404120 Chongqing, China.
Xiaocheng LiuWanzhou Shanghai Hospital, Chongqing, No. 112 Shanghai Street, Wanzhou District, 404120 Chongqing, China.
Chenghong LiDepartment of Clinical and Military Laboratory Medicine, College of Pharmacy and Laboratory Medicine, Army Medical University, No. 30 Gaotanyan Street, Shapingba District, 400038 Chongqing, China.
Yang XiangDepartment of Clinical and Military Laboratory Medicine, College of Pharmacy and Laboratory Medicine, Army Medical University, No. 30 Gaotanyan Street, Shapingba District, 400038 Chongqing, China.
Hui HuangDepartment of Clinical and Military Laboratory Medicine, College of Pharmacy and Laboratory Medicine, Army Medical University, No. 30 Gaotanyan Street, Shapingba District, 400038 Chongqing, China.
Lina WangDepartment of Clinical and Military Laboratory Medicine, College of Pharmacy and Laboratory Medicine, Army Medical University, No. 30 Gaotanyan Street, Shapingba District, 400038 Chongqing, China.
Huamin LiuDepartment of Clinical and Military Laboratory Medicine, College of Pharmacy and Laboratory Medicine, Army Medical University, No. 30 Gaotanyan Street, Shapingba District, 400038 Chongqing, China.
Xiaolong WangEmergency Department, Second Affiliated Hospital of Chongqing Medical University, 400010 Chongqing, China.
Junsong ZhengDepartment of Clinical and Military Laboratory Medicine, College of Pharmacy and Laboratory Medicine, Army Medical University, No. 30 Gaotanyan Street, Shapingba District, 400038 Chongqing, China.ORCID 0000-0002-5248-4209

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The diagnosis and treatment of acute pancreatitis remain challenging due to the limitations of diagnostic methods, which often result in delayed treatment and suboptimal outcomes. This underscores the need for innovative diagnostic strategies to enable early detection and improve therapeutic interventions. Electrochemiluminescence (ECL)-based biosensors have emerged as a promising solution, offering advantages such as cost-effectiveness, ease of use, and high sensitivity. This study introduces an innovative ECL biosensor design, which incorporates a DNA tetrahedron as a structural scaffold, a double swing arm mechanism for enhanced motion control, and a track-based signal regulation system. This design significantly enhanced the operating efficiency and controllability of DNA walkers. The system utilizes ferrocene (Fc) as a signal quenching agent, with its electrochemical signal restored upon interaction with miRNA24-3p, a biomarker for acute pancreatitis. The platform features a composite luminescent material─tris(2,2'-bipyridine) dichlororuthenium(II)@goldnanoparticles@single-walled carbon nanotubes (Ru(bpy)

Indexed as

Biosensing TechniquesDNAElectrochemical TechniquesGoldLuminescent MeasurementsMetal NanoparticlesMicroRNAsNanotubes, CarbonHumansLimit of DetectionDNAGoldMicroRNAsNanotubes, Carbon

Identifiers

PMID40371917
PMCPMC12121624

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.