Evidence map›Paper›PMID 40371875›Full record

ArticleTransfusion2025

A prospective non-inferiority trial of pathogen reduced platelets compared to non-pathogen reduced platelets for correction of viscoelastic platelet function testing in cardiac surgery.

Magali J Fontaine, Jackline J M Lasola, Aidaelis Martinez-Hernandez, Juliana N Marshall, Soren Bentzen, Min Zhan, Parvez M Lokhandwala, Kenichi Tanaka, Carlos H Villa, Alexis Jones and 2 more

Abstract readEquivalence TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Transfusion, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Magali J FontaineDepartment of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0001-6731-9516
Jackline J M LasolaDepartment of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Aidaelis Martinez-HernandezDepartment of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Juliana N MarshallDepartment of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Soren BentzenDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Min ZhanDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0002-3776-7884
Parvez M LokhandwalaDepartment of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Kenichi TanakaDepartment of Anesthesia, University of Oklahoma Health Sciences Center, Oklahoma, Oklahoma, USA.ORCID https://orcid.org/0000-0002-5051-1365
Carlos H VillaOffice of Blood Research and Review, Center for Biologics Evaluation and Research (CBER), US Food and Drug Administration, Silver Spring, Maryland, USA.ORCID https://orcid.org/0000-0002-4632-4751
Alexis JonesDepartment of Anesthesia, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Chintamani D AtreyaOffice of Blood Research and Review, Center for Biologics Evaluation and Research (CBER), US Food and Drug Administration, Silver Spring, Maryland, USA.ORCID https://orcid.org/0000-0001-7393-2157
Reney A HendersonDepartment of Anesthesia, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Funding

UMB Postbaccalaureate Research Education ProgramR25GM113262 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE · PI ANTALIS, TONI M, CAREY, GREGORY B · 2016 to 2025
$3.2M
NIGMS NIH HHS R25 GM113262NIH HHS R25-GM113262-09U.S. Food and Drug Administration
6 · The paper itself

Abstract

backgroundCardiac surgery on cardiopulmonary bypass (CPB) may alter platelet (PLT) function causing bleeding. The goal of this study is to evaluate the hemostatic effect of PRT-PLTs compared to untreated PLTs stored in platelet additive solution (PAS) following transfusion in bleeding patients undergoing cardiac surgery on CPB.

methodsIn this single-center, prospective single-blinded two-arm noninferiority trial, patients being weaned off CPB were allocated to either a PRT-PLT or a standard PAS-PLT. The primary outcome was the change in maximum amplitude (ΔMA) on thromboelastographic testing (TEG) from pre- to post-transfusion. The non-inferiority margin was chosen as 50% of the ΔMA observed with PAS-PLT using a 1-sided 95% confidence interval. The secondary outcomes included the volume of chest tube drainage (CTD) and the number of blood products transfused during the first 24 h post-surgery.

resultsA modified intention-to-treat analysis included 90 patients (48 PRT-PLTs; 42 PAS-PLTs). The ΔMA for PRT-PLT was 2.93 mm (95% CI 1.52-4.34) and was lower than that achieved with PAS-PLT at 5.68 mm (95% CI 3.26-8.09) (2-tailed p = .052). The ratio of ΔMA for PRT-PLT relative to PAS-PLT was estimated at .52 with a 90% confidence interval (.29, .89) and did not meet the non-inferiority criterion (>.5). The CTD and the number of blood products transfused during the first 24 h post-surgery were similar in both arms.

conclusionPRT-PLT transfusion results in lower responses in viscoelastic testing compared to PAS-PLT, although clinical outcomes with respect to blood component utilization and chest tube drainage were similar.

Indexed as

Blood PlateletsCardiac Surgical ProceduresCardiopulmonary BypassPlatelet Function TestsPlatelet TransfusionAgedFemaleHumansMaleMiddle AgedProspective StudiesSingle-Blind MethodThrombelastographyblood component preparationshemostasisplatelet transfusion

Identifiers

PMID40371875
PMCPMC12227164

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.