Evidence map›Paper›PMID 40371815›Full record

ArticleBioanalysis2025

Enhancing clinical detection of polyunsaturated fatty acids (PUFAs) in pregnancy: a robust LC-MS/MS methodology.

Xu Yan, Shuang Wang, Ying Li, Li Cui, Zhitu Zhu, Haiwen Liu, Lu Wang, Yanru Zhu, Furong Zhao, Ping Yang

Abstract read
In one paragraph

Article in Bioanalysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xu YanDepartment of Cardiology, China-Japan Union Hospital of Jilin University, Changchun, China.
Shuang WangLiaoning Provincial Key Laboratory of Clinical Oncology Metabonomics, Jinzhou Medical University, Jinzhou, China.ORCID 0009-0003-8005-2248
Ying LiLiaoning Provincial Key Laboratory of Clinical Oncology Metabonomics, Jinzhou Medical University, Jinzhou, China.
Li CuiClinical Research Department, Dalian Boyuan Medical Technology Co. Ltd, Dalian, China.
Zhitu ZhuLiaoning Provincial Key Laboratory of Clinical Oncology Metabonomics, Jinzhou Medical University, Jinzhou, China.
Haiwen LiuLiaoning Provincial Key Laboratory of Clinical Oncology Metabonomics, Jinzhou Medical University, Jinzhou, China.
Lu WangClinical Research Department, Dalian Boyuan Medical Technology Co. Ltd, Dalian, China.
Yanru ZhuClinical Research Department, Dalian Boyuan Medical Technology Co. Ltd, Dalian, China.
Furong ZhaoLiaoning Provincial Key Laboratory of Clinical Oncology Metabonomics, Jinzhou Medical University, Jinzhou, China.ORCID 0009-0004-4484-4843
Ping YangDepartment of Cardiology, China-Japan Union Hospital of Jilin University, Changchun, China.ORCID 0000-0001-7960-6248

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsOmega-3 (

methodsSample preparative process consisted of non-derivatized alkali hydrolyzing and liquid-liquid extraction followed by reconstituting after being blown dry with nitrogen, and the total chromatographic run time was only 5.6 min.

resultsThe LC-MS/MS method was validated according to current national and international guidelines. Acceptable reproducibility and accuracy were shown based on the intra-day precision was 1.79%-7.02%, the inter-day precision was 0.01%-5.63%, and the accuracy was 87.42%-102.78%. The correlation coefficients of linearity were >0.9930. All measured plasma individual PUFAs levels in pregnant women significantly increased, apart from eicosapentaenoic acid (EPA, C20:5n3) and

conclusionThis method could be a valuable tool for 10 kinds of

Indexed as

Fatty Acids, UnsaturatedTandem Mass SpectrometryAdultChromatography, LiquidFatty Acids, Omega-3Fatty Acids, Omega-6FemaleHumansLiquid Chromatography-Mass SpectrometryPregnancyReproducibility of ResultsFatty Acids, Omega-3Fatty Acids, Omega-6Fatty Acids, UnsaturatedLiquid chromatography-tandem mass spectrometrynutritional assessmentomega-3 polyunsaturated fatty acidsomega-6 polyunsaturated fatty acidspregnant women

Identifiers

PMID40371815
PMCPMC12087922

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.