Evidence map›Paper›PMID 40371587›Full record

Observational studyJournal of the American Heart Association2025

Role of Heart Rate Recovery in Chronic Heart Failure: Results From the MyoVasc Study.

David Velmeden, Jakob Söhne, Alexander Schuch, Silav Zeid, Andreas Schulz, Sven-Oliver Troebs, Felix Müller, Marc W Heidorn, Gregor Buch, Noémie Belanger and 7 more

Registry-linked trialAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04064450 (MyoVasc - An Epidemiological Cohort Study to Investigate the Development and Progression of Heart Failure and the Interaction With Vascular Disease), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04064450 active not recruitingnot on this map

MyoVasc - An Epidemiological Cohort Study to Investigate the Development and Progression of Heart Failure and the Interaction With Vascular Disease

TypeobservationalSponsorJohannes Gutenberg University MainzRan2013 to 2028Enrolled3,289ConditionsHeart Failure
3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Beyond distance and heart rate: Reading 6-minute walk testWorld journal of experimental medicine · 2026
    Article
  5. Observational
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

David VelmedenPreventive Cardiology and Preventive Medicine, Department of Cardiology University Medical Center of the Johannes Gutenberg University Mainz Mainz Germany.
Jakob SöhnePreventive Cardiology and Preventive Medicine, Department of Cardiology University Medical Center of the Johannes Gutenberg University Mainz Mainz Germany.
Alexander SchuchPreventive Cardiology and Preventive Medicine, Department of Cardiology University Medical Center of the Johannes Gutenberg University Mainz Mainz Germany.
Silav ZeidPreventive Cardiology and Preventive Medicine, Department of Cardiology University Medical Center of the Johannes Gutenberg University Mainz Mainz Germany.
Andreas SchulzPreventive Cardiology and Preventive Medicine, Department of Cardiology University Medical Center of the Johannes Gutenberg University Mainz Mainz Germany.
Sven-Oliver TroebsPreventive Cardiology and Preventive Medicine, Department of Cardiology University Medical Center of the Johannes Gutenberg University Mainz Mainz Germany.ORCID 0000-0003-4570-2025
Felix MüllerPreventive Cardiology and Preventive Medicine, Department of Cardiology University Medical Center of the Johannes Gutenberg University Mainz Mainz Germany.
Marc W HeidornPreventive Cardiology and Preventive Medicine, Department of Cardiology University Medical Center of the Johannes Gutenberg University Mainz Mainz Germany.ORCID 0000-0003-0134-2726
Gregor BuchPreventive Cardiology and Preventive Medicine, Department of Cardiology University Medical Center of the Johannes Gutenberg University Mainz Mainz Germany.ORCID 0000-0002-9963-1245
Noémie BelangerPreventive Cardiology and Preventive Medicine, Department of Cardiology University Medical Center of the Johannes Gutenberg University Mainz Mainz Germany.
Wilfried DinhBayer AG, Research and Development, Translational Clinical Medicine, Experimental Medicine 1 Wuppertal Germany.ORCID 0000-0001-9929-4253
Thomas MondritzkiResearch & Early Development, Clinical Experimentation CV, BAYER AG Wuppertal Germany.ORCID 0000-0003-0162-773X
Karl J LacknerGerman Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main Mainz Germany.
Tommaso GoriGerman Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main Mainz Germany.
Thomas MünzelGerman Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main Mainz Germany.ORCID 0000-0001-5503-4150
Philipp S WildPreventive Cardiology and Preventive Medicine, Department of Cardiology University Medical Center of the Johannes Gutenberg University Mainz Mainz Germany.ORCID 0000-0003-4413-9752
Jürgen H ProchaskaPreventive Cardiology and Preventive Medicine, Department of Cardiology University Medical Center of the Johannes Gutenberg University Mainz Mainz Germany.ORCID 0000-0001-5078-9992

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCardiac autonomic dysfunction is associated with heart failure (HF). Reduced heart rate recovery (HRR) indicates impaired parasympathetic reactivation after physical activity. Heart rate recovery 60 seconds after peak effort (HRR

methodsData from the MyoVasc study (NCT04064450; N=3289) were analyzed. Participants underwent standardized clinical phenotyping including cardiopulmonary exercise testing. HRR

resultsThe analysis sample comprised 1289 individuals (median age, 66.0 [interquartile range {IQR}, 58.0-73.0] years, 30.4% women) ranging from stage B to stage C/D according to the universal definition of HF. Age, sex, smoking, obesity, peripheral artery disease, and chronic kidney disease were identified as determinants of HRR

conclusionsHRR

Indexed as

Heart FailureHeart RateAgedChronic DiseaseExercise TestFemaleHumansMaleMiddle AgedRecovery of FunctionRisk FactorsStroke VolumeTime Factorsall‐cause deathautonomic dysfunctionheart failureheart rate recoveryprognosisworsening of heart failure

Identifiers

PMID40371587
PMCPMC12184589

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.