ArticleJournal of the American Heart Association2025
Association of Cardiovascular-Kidney-Metabolic Syndrome With Cognitive Decline and Dementia: The ARIC Study Insights.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Cardiovascular-Kidney-Metabolic Syndrome, Healthy Lifestyles, and Risk of Cancer Incidence and Mortality: A Prospective Cohort Study.International journal of cancer · 2026Article
- C-reactive protein-triglyceride-glucose index and incident mild cognitive impairment among patients with cardiovascular-kidney-metabolic syndrome: a dual-cohort prediction and double machine learning analysis.Journal of endocrinological investigation · 2026Article
- Emerging multidimensional biomarker system for cardiovascular-kidney-metabolic syndrome: from multi-omics integration to clinical artificial intelligence.Cardiovascular diabetology · 2026Review
- Cardiovascular-kidney-metabolic syndrome stages 0-3 and cognitive decline in Chinese adults: a longitudinal analysis from the China health and retirement longitudinal study.BMC cardiovascular disorders · 2026Article
- Relative contributions of lifestyle factors to stage-specific progression and mortality in cardiovascular-kidney-metabolic syndrome: a prospective cohort study with multi-state models.Frontiers in public health · 2026Article
- Comparative associations of cumulative cholesterol-HDL-glucose index and triglyceride-glucose index with risk of cardiovascular disease in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3: a prospective cohort study.Frontiers in endocrinology · 2026Article
- Association of metabolic syndrome severity with cognitive decline among Chinese older adults: evidence from two prospective cohort studies.Frontiers in neuroscience · 2026Article
- Comparison of Cardiorenal Syndrome and Heart Failure: A Preliminary Study of Clinical, Cognitive, and Emotional Aspects.NeuroSci · 2025Article
- Cardiovascular-kidney-metabolic syndrome: The evolving perioperative implications.Journal of anaesthesiology, clinical pharmacologyArticle
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Authors and funding
13 authors.
Funding
Abstract
backgroundCardiovascular-kidney-metabolic (CKM) syndrome is an emerging clinical entity emphasizing the need for a holistic approach to patient care. The relationship between CKM syndrome and cognitive decline or dementia remains undetermined.
methodsA total of 10 426 participants in the ARIC (Atherosclerosis Risk in Communities) study, classified into 4 CKM risk categories at baseline (visit 2: 1990-1992): low risk (≤5%), borderline risk (5%-7.4%), intermediate risk (7.5%-19.9%), and high risk (≥20%), were used to investigate the associations between CKM risk and cognitive decline or dementia using regression analysis.
resultsElevated CKM risk level is significantly associated with increased risks of cognitive decline and dementia incidence. Each 1-unit increase in CKM risk level is linked to a 6% higher risk of dementia progression in the fully adjusted model.
conclusionsThese findings highlight a strong association between CKM syndrome and cognitive decline or incident dementia, underscoring the importance of early interventions.
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