Evidence map›Paper›PMID 40371577›Full record

ArticleCancer medicine2025

Rising Threat: Long-Term Trends in the Incidence and Mortality of Thymic Epithelial Tumor.

Zishan Chen, Shiwen Liu, Chunting Chen, Jinmang Zhuang, Xinying Xu, Maolin Liu, Fancai Lai, Fei He

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PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zishan ChenDepartment of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, China.
Shiwen LiuDepartment of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, China.
Chunting ChenDepartment of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, China.
Jinmang ZhuangDepartment of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, China.
Xinying XuDepartment of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, China.
Maolin LiuDepartment of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, China.
Fancai LaiDepartment of Thoracic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Fei HeDepartment of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, China.ORCID https://orcid.org/0000-0002-9119-9056

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAn upward trend in the incidence of thymic epithelial tumors (TETs) has been reported over the past few decades, but because of its rarity, little is currently known about its epidemiological trends. This study examined temporal trends in the incidence and mortality of TETs in the US and explored these trends in population subgroups while investigating important factors that influence their prognosis.

methodsA retrospective, population-based study was conducted using nationally representative data from the Surveillance, Epidemiology, and End Results program, and 4979 patients diagnosed with TETs from 2000 to 2020 were evaluated. Associated population data were used to determine age-adjusted incidence and mortality, and 5-year TET-specific mortality (SM). Trends were assessed for the entire cohort, as well as for particular subgroups, including thymoma and thymic carcinoma.

resultsFrom 2000 to 2020, the overall incidence and mortality of TETs were 2.769 and 1.203 per million person-years, respectively. Both the age-adjusted incidence and mortality of TETs increased over the study period, with increases occurring across almost all ethnic groups, histological subtypes, and stages. Multivariate analysis revealed that age, World Health Organization histological type (B1, B2, and B3 thymoma and thymic carcinoma), Masaoka-Koga stage (IIB and III/IV), maximum tumor diameter (5-10 and > 10 cm), surgery, and chemotherapy were independently associated with TET-SM.

conclusionsThe incidence and mortality of TETs have steadily increased over time, and these trends might be related to the widespread use of computed tomography for lung cancer screening and the increasing number of TETs found incidentally. The study also identified several important factors independently associated with TET-SM, suggesting that early diagnosis and surgical intervention are critical to achieving good prognoses.

Indexed as

Neoplasms, Glandular and EpithelialThymus NeoplasmsAdolescentAdultAgedAged, 80 and overFemaleHumansIncidenceMaleMiddle AgedMortalityNeoplasm StagingPrognosisRetrospective StudiesSEER ProgramincidencemortalityprognosisSEERThymic epithelial tumor

Identifiers

PMID40371577
PMCPMC12079087

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