ReviewCNS neuroscience & therapeutics2025
Blood-Brain Barrier (BBB) Dysfunction in CNS Diseases: Paying Attention to Pericytes.
Review in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Sex- and age-specific associations ofAnnals of medicine · 2026Article
- Long-term clinical and biomarker observations following rituximab exposure in two siblings with CSF1R-related leukoencephalopathy: a preliminary familial case series.Communications medicine · 2026Article
- Astrocyte-Microglia Crosstalk in Post-Hemorrhagic Neurovascular Microenvironment: Mechanistic Nodes, Cross-Stroke Comparisons, and Therapeutic Reprogramming.Translational stroke research · 2026Review
- Progress in Understanding Brain Injury After Cardiopulmonary Bypass in Cardiac Surgery: A Narrative Review.Reviews in cardiovascular medicine · 2026Review
- Early identification of vascular cognitive impairment from a multimodal perspective: a combined diagnosis from targeted cognitive assessments, imaging biomarkers, and molecular fluid biomarkers to ecological behavioral characteristics.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- The Gut-Brain-Immune Axis: Multi-Omics Insights into Neurodegenerative and Metabolic Diseases.Cells · 2026Review
- A Microfluidic Framework for Neuroprotective Compound Triage Across Ischemia and Neurodegeneration.Molecules (Basel, Switzerland) · 2026Review
- From Cerebrovascular Injury to Vascular Cognitive Impairment and Dementia: Therapeutic Potential of Stem Cell-Derived Extracellular Vesicles.Biomedicines · 2026Review
- Pericytes as key mediators of microenvironmental signaling crosstalk: implications in vascular diseases and cancer.Frontiers in cell and developmental biology · 2026Review
- The role of remote ischemic conditioning in ischemic stroke: neuroprotective mechanisms and future directions.Frontiers in immunology · 2026Review
- Astrocyte-blood-brain barrier crosstalk in cerebral small vessel disease: linking barrier dysfunction to neurovascular failure.Frontiers in neurology · 2026Review
- Brain pericytes upregulate glutamate uptake by astrocytesIBRO neuroscience reports · 2025Article
- Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acids: advances and challenges.Journal of nanobiotechnology · 2025Review
- The Role of Blood-Brain Barrier in Brain Cancer: From Pathophysiology to Therapeutic Approaches.Cancer control : journal of the Moffitt Cancer CenterReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundDysfunction of the blood-brain barrier (BBB) is an important pathological mechanism in central nervous system (CNS) diseases and can trigger a series of pathological reactions, such as neuroinflammatory responses, oxidative stress, immune infiltration, etc., thereby worsening brain damage. However, pericytes are often overlooked by researchers, and no review research has yet summarized the mechanism by which pericytes contribute to BBB dysfunction in CNS diseases.
resultsTherefore, this review explores the pathophysiology of BBB dysfunction in CNS diseases and provides a detailed account of the biological characteristics of pericytes, especially the controversy over their biomarkers. Subsequently, we review the role of pericytes in CNS diseases such as Alzheimer's disease, vascular dementia, multiple sclerosis, ischemic stroke, and hemorrhagic stroke, with a particular focus on the role of pericytes in BBB dysfunction. In addition, we also discuss treatments based on pericytes, such as regenerative medicine that induces pericyte differentiation and Pericyte-Extracellular Vesicles.
conclusionsThis review aims to provide a more comprehensive understanding and guidance on the role of pericytes in BBB dysfunction in CNS diseases and serve clinical treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.