Evidence map›Paper›PMID 40371535›Full record

ArticleCirculation research2025

SM22α-Lineage Perivascular Stromal Cells Contribute to Abdominal Aortic Aneurysm.

Xiaoxi Pan, Run Zhang, Bingling Lu, Siyuan Chen, Hongjin Chen, Mengyao Li, Le Qin, Zhiyun Song, Yi Yang, Zhe Wang and 7 more

Abstract read
PubMed Publisher
In one paragraph

Article in Circulation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
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  5. Article
  6. Emerging Mechanisms of Abdominal Aortic Aneurysm.Current atherosclerosis reports · 2026
    Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Xiaoxi Pan *Department of Cardiovascular Medicine, State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Department of Hypertension, Ruijin Hospital and Shanghai Institute of Hypertension (X.P., R.Z., S.C., H.C., M.L., J.W., P.G.), Shanghai Jiao Tong University School of Medicine, China.ORCID 0000-0002-6955-9975
Run Zhang *Department of Cardiovascular Medicine, State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Department of Hypertension, Ruijin Hospital and Shanghai Institute of Hypertension (X.P., R.Z., S.C., H.C., M.L., J.W., P.G.), Shanghai Jiao Tong University School of Medicine, China.
Bingling LuSchool of Biomedical Engineering, Shanghai Jiao Tong University, China (B.L., Z.S., L.Z.).
Siyuan ChenDepartment of Cardiovascular Medicine, State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Department of Hypertension, Ruijin Hospital and Shanghai Institute of Hypertension (X.P., R.Z., S.C., H.C., M.L., J.W., P.G.), Shanghai Jiao Tong University School of Medicine, China.
Hongjin ChenDepartment of Cardiovascular Medicine, State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Department of Hypertension, Ruijin Hospital and Shanghai Institute of Hypertension (X.P., R.Z., S.C., H.C., M.L., J.W., P.G.), Shanghai Jiao Tong University School of Medicine, China.ORCID 0009-0002-1820-2244
Mengyao LiDepartment of Cardiovascular Medicine, State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Department of Hypertension, Ruijin Hospital and Shanghai Institute of Hypertension (X.P., R.Z., S.C., H.C., M.L., J.W., P.G.), Shanghai Jiao Tong University School of Medicine, China.ORCID 0009-0003-0315-2464
Le QinDepartment of Radiology, Ruijin Hospital (L.Q., F.Y.), Shanghai Jiao Tong University School of Medicine, China.ORCID 0000-0002-8244-8217
Zhiyun SongSchool of Biomedical Engineering, Shanghai Jiao Tong University, China (B.L., Z.S., L.Z.).ORCID 0000-0002-6223-1766
Yi YangDepartment of Cardiovascular Surgery, Ruijin Hospital (Y.Y., Z.W.), Shanghai Jiao Tong University School of Medicine, China.ORCID 0000-0001-8913-0220
Zhe WangDepartment of Cardiovascular Surgery, Ruijin Hospital (Y.Y., Z.W.), Shanghai Jiao Tong University School of Medicine, China.ORCID 0009-0007-5301-013X
Fuhua YanDepartment of Radiology, Ruijin Hospital (L.Q., F.Y.), Shanghai Jiao Tong University School of Medicine, China.ORCID 0000-0002-5910-1506
Aijun SunDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China (A.S.).ORCID 0000-0003-1488-0937
Fang WuShanghai Clinical Research Center for Aging and Medicine, Department of Geriatrics, Ruijin Hospital (F.W.), Shanghai Jiao Tong University School of Medicine, China.
Lichi ZhangSchool of Biomedical Engineering, Shanghai Jiao Tong University, China (B.L., Z.S., L.Z.).ORCID 0000-0003-4396-4566
Jiguang WangDepartment of Cardiovascular Medicine, State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Department of Hypertension, Ruijin Hospital and Shanghai Institute of Hypertension (X.P., R.Z., S.C., H.C., M.L., J.W., P.G.), Shanghai Jiao Tong University School of Medicine, China.
Tomasz J GuzikDepartment of Medicine, Jagiellonian University, Colelgium Medicum, Krakow, Poland (T.J.G.).ORCID 0000-0002-5039-7849
Pingjin GaoDepartment of Cardiovascular Medicine, State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Department of Hypertension, Ruijin Hospital and Shanghai Institute of Hypertension (X.P., R.Z., S.C., H.C., M.L., J.W., P.G.), Shanghai Jiao Tong University School of Medicine, China.ORCID 0000-0002-7750-3314

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPerivascular adipose tissue (PVAT) is a key regulator of vascular dysfunction. Impairment of PVAT phenotypic plasticity with aging may play a role in vascular pathology including abdominal aortic aneurysms (AAAs). Yet, the mechanisms underlying PVAT plasticity in aneurysm pathogenesis remain elusive.

methodsSingle-cell RNA sequencing was performed on perivascular stromal cells (PVSCs) from young (2- to 3-month-old) and aged (18- to 20-month-old) mice. The expression of PGC-1α (peroxisome proliferator-activated receptor gamma coactivator-1α) was measured in PVAT of aged mice and human aneurysm samples. Loss- and gain-of-function approaches were used to investigate the role of SM22α (Smooth Muscle 22-Alpha)-lineage PVSCs-derived PGC-1α in aneurysm development. Molecular mechanisms were explored through transcriptome and functional studies in young and aged mice, SM22α

resultsSM22α

conclusionsPGC-1α deficiency in SM22α-lineage PVSCs disrupts the balance between adipogenic and myofibrogenic differentiation through regulating YAP signaling, ultimately promoting AAA development. Radiomics assessment may present a promising noninvasive approach for PVAT evaluation in aneurysms, offering valuable potential for clinical research.

Indexed as

Adipose TissueAortic Aneurysm, AbdominalCell LineageMicrofilament ProteinsMuscle ProteinsStromal CellsAnimalsDisease Models, AnimalHumansMaleMiceMice, Inbred C57BLPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaMicrofilament ProteinsMuscle ProteinsPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPPARGC1A protein, humanPpargc1a protein, mousetransgelinadipose tissueagingaortic aneurysmaortic aneurysm, abdominalsingle-cell gene expression analysis

Identifiers

PMID40371535

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.