Evidence map›Paper›PMID 40371475›Full record

ArticleCirculation research2025

Waseem Chauhan, Sudharshan Sj, Shirin Ferdowsi, Sweta Kafle, Rahima Zennadi

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Waseem ChauhanDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN.
Sudharshan SjDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN.
Shirin FerdowsiDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN.
Sweta KafleDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN.
Rahima ZennadiDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN.ORCID 0009-0000-1371-5695

Funding

Oxidative stress mechanisms regulating gamma-globin gene transcription in sickle cell diseaseR01HL160697 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI Rahima Zennadi · 2022 to 2026
$1.7M
The Role of RBC Reactive Oxygen Species in Regulating Thrombotic Events During AgingR01AG068035 · NIA · DUKE UNIVERSITY · PI ZENNADI, RAHIMA · 2021 to 2023
$1.3M
NHLBI NIH HHS R01 HL160697NIA NIH HHS R01 AG068035
6 · The paper itself

Abstract

backgroundIn sickle cell disease (SCD), erythrocyte reactive oxygen species (ROS) production and oxidative stress play a critical role in vaso-occlusion, a hallmark of SCD. Small noncoding nucleolar RNAs (snoRNAs) of the

methodsTo determine whether sickle RBC ROS levels are associated with

resultsExcessive ROS production in sickle RBCs of patients with SCD is associated with high

conclusions

Indexed as

Anemia, Sickle CellErythrocytesRibosomal ProteinsRNA, Small NucleolarAnimalsFemaleHumansK562 CellsMaleMiceMice, KnockoutOxidative StressReactive Oxygen SpeciesReactive Oxygen SpeciesRibosomal ProteinsRNA, Small Nucleolaranemia, sickle cellantioxidantsendothelium, vascularreactive oxygen speciesRNA, small nucleolar

Identifiers

PMID40371475
PMCPMC12270761

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.