Article in Arteriosclerosis, thrombosis, and vascular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Mary E SchulzDepartment of Pharmacology (M.E.S., V.L.A., T.B.G., S.E. Braun, J.A.C.-G.), Tulane University School of Medicine, New Orleans, LA.ORCID 0009-0002-1553-6337
Victoria L AkerstromDepartment of Pharmacology (M.E.S., V.L.A., T.B.G., S.E. Braun, J.A.C.-G.), Tulane University School of Medicine, New Orleans, LA.
Kejing SongCenter for Translational Research in Infection and Inflammation (K.S.), Tulane University School of Medicine, New Orleans, LA.ORCID 0000-0003-0976-5109
Sarah E BroyhillDepartment of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia (S.E. Broyhill, M.L., M.D.L., C.E.N., T.L.D., S.D.Z.).
Min LiDepartment of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia (S.E. Broyhill, M.L., M.D.L., C.E.N., T.L.D., S.D.Z.).ORCID 0009-0001-6648-375X
Michelle D LambertDepartment of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia (S.E. Broyhill, M.L., M.D.L., C.E.N., T.L.D., S.D.Z.).
Tatia B GoldbergDepartment of Pharmacology (M.E.S., V.L.A., T.B.G., S.E. Braun, J.A.C.-G.), Tulane University School of Medicine, New Orleans, LA.
Raghu P KataruDivision of Plastic and Reconstructive Surgery, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY (R.P.K., J.S., B.J.M.).ORCID 0000-0003-1315-7982
Jinyeon ShinDivision of Plastic and Reconstructive Surgery, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY (R.P.K., J.S., B.J.M.).
Stephen E BraunDepartment of Pharmacology (M.E.S., V.L.A., T.B.G., S.E. Braun, J.A.C.-G.), Tulane University School of Medicine, New Orleans, LA.ORCID 0000-0002-4521-2678
Charles E NortonDepartment of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia (S.E. Broyhill, M.L., M.D.L., C.E.N., T.L.D., S.D.Z.).ORCID 0000-0001-9442-4039
Rafael S CzepielewskiImmunology Center of Georgia, Georgia Cancer Center, Department of Physiology, Medical College of Georgia, Augusta University (R.S.C.).ORCID 0000-0002-2475-3838
Babak J MehraraDivision of Plastic and Reconstructive Surgery, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY (R.P.K., J.S., B.J.M.).ORCID 0000-0001-5717-697X
Timothy L DomeierDepartment of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia (S.E. Broyhill, M.L., M.D.L., C.E.N., T.L.D., S.D.Z.).ORCID 0000-0003-0340-6551
Scott D ZawiejaDepartment of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia (S.E. Broyhill, M.L., M.D.L., C.E.N., T.L.D., S.D.Z.).ORCID 0000-0003-4658-3179
Jorge A Castorena-GonzalezDepartment of Pharmacology (M.E.S., V.L.A., T.B.G., S.E. Braun, J.A.C.-G.), Tulane University School of Medicine, New Orleans, LA.ORCID 0000-0001-5252-375X
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
Mechanisms of fibrosis in post-surgical lymphedemaR01HL111130 · NHLBI · SLOAN-KETTERING INST CAN RESEARCH · PI MEHRARA, BABAK J · 2012 to 2021
$7.2M
Cardiomyocyte TRPV4 and cardiac dysfunction following ischemia-reperfusion in the aged heart.R01HL136292 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI Timothy Lee Domeier · 2017 to 2026
$3.5M
Mechanisms of racial disparity in breast cancer-related lymphedemaR01CA278599 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Andrea Barrio, Babak J Mehrara · 2023 to 2026
$2.9M
Trpv4 regulation of lymphatic vascular function: Implications in metabolic syndromeR01HL168568 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI Jorge Augusto Castorena · 2023 to 2026
$1.9M
Regulation of lymphatic muscle cell function by store operated calcium entry signalingR01HL175083 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI Scott D. Zawieja · 2024 to 2026
$1.7M
Female sex protects vascular smooth muscle cells from mitochondrial depolarization to oxidative stressR01NS134690 · NINDS · UNIVERSITY OF MISSOURI-COLUMBIA · PI Charles E Norton · 2024 to 2026
$1.1M
The Regulation of Lymphatic Muscle Cell Pacemaking by Intracellular Calcium SignalsR00HL143198 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI ZAWIEJA, SCOTT D. · 2021 to 2023
$747k
Molecular mechanisms of age-related lymphatic dysfunctionR21AG076132 · NIA · SLOAN-KETTERING INST CAN RESEARCH · PI MEHRARA, BABAK J · 2022 to 2023
$487k
Role of epidermis in regulating inflammatory skin manifestations of post-surgical lymphedemaR21AR081076 · NIAMS · SLOAN-KETTERING INST CAN RESEARCH · PI MEHRARA, BABAK J · 2023 to 2024
backgroundDysregulation of TRPV4 (transient receptor potential vanilloid type 4)-mediated signaling has been associated with inflammation and tissue fibrosis, both of which are key features in the pathophysiology of lymphatic system diseases; however, the expression and functional roles of lymphatic TRPV4 channels remain largely unexplored.
methodsWe generated a single-cell RNA sequencing dataset from microdissected mouse collecting lymphatic vessels to characterize the expression of
resultsWe characterized the single-cell transcriptome of collecting lymphatic vessels and surrounding tissues.
conclusionsOur results uncovered a novel mechanism of lymphatic contractile dysregulation mediated by the crosstalk between TRPV4-expressing myeloid cells, including LYVE1+ macrophages, and lymphatic muscle cells or lymphatic endothelial cells. These findings highlight potentially important roles of TRPV4 channels in lymphatic dysfunction associated with inflammation, including secondary lymphedema.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Regulation of Collecting Lymphatic Vessel Contractile Function by TRPV4 Channels. · full record | OpenQuestion