Evidence map›Paper›PMID 40371393›Full record

ArticleFrontiers in cell and developmental biology2025

Solid stress compression enhances breast cancer cell migration through the upregulation of Interleukin-6.

Farouq Azizan, Ryna Shireen Sheriff, Corinna Jie Hui Goh, Keng Hwee Chiam, Cheng-Gee Koh

Abstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Farouq AzizanSchool of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
Ryna Shireen SheriffSchool of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
Corinna Jie Hui GohBioinformatics Institute, Agency for Science, Technology and Research (A*Star), Biopolis, Singapore, Singapore.
Keng Hwee ChiamBioinformatics Institute, Agency for Science, Technology and Research (A*Star), Biopolis, Singapore, Singapore.
Cheng-Gee KohSchool of Biological Sciences, Nanyang Technological University, Singapore, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Apart from biochemical signals, tumour cells respond to biophysical and mechanical cues from their environment. The mechanical forces from the tumour microenvironment could be in the form of shear stress, tension, or solid stress compression. In this study, we explore the effects of solid stress compression on tumour cells. Solid stress compression, a prevalent biomechanical stimulus accumulated during tumour growth, has been shown to enhance invasive and metastatic phenotypes in cancer cells. However, the underlying molecular mechanism that elicits this aggressive metastatic phenotype, especially in breast cancer, is not extensively studied. Using an established 2D

Indexed as

cell migrationInterleukin-6mechanosensitive genessolid stress compressiontranscriptome

Identifiers

PMID40371393
PMCPMC12077316

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.