Evidence map›Paper›PMID 40371381›Full record

ReviewInternational journal of inflammation2025

Are Salivary and Plasma Levels of Toll-Like Receptors 2 and 4 Elevated in Subjects With Chronic Periodontitis?: A Systematic Review and Meta-Analysis.

Mario Alberto Alarcón-Sánchez, Ruth Rodríguez-Montaño, Sarah Monserrat Lomelí-Martínez, Cristina Hermila Martínez-Bugarin, Seyed Ali Mosaddad, Artak Heboyan

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of inflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mario Alberto Alarcón-SánchezMolecular Biology in Medicine Program, University Center of Health Sciences, University of Guadalajara (CUCS-UdeG), Guadalajara 44340, Jalisco, Mexico.ORCID https://orcid.org/0000-0001-6727-7969
Ruth Rodríguez-MontañoInstitute of Research in Dentistry, Department of Integral Dental Clinics, University Center of Health Sciences, University of Guadalajara (CUCS-UdeG), Guadalajara 44340, Jalisco, Mexico.ORCID https://orcid.org/0000-0002-0712-0334
Sarah Monserrat Lomelí-MartínezDepartment of Medical and Life Sciences, La Ciénega University Center, University of Guadalajara (CUCIÉNEGA-UdeG), Ocotlán 47820, Jalisco, Mexico.
Cristina Hermila Martínez-BugarinInstitute of Research in Dentistry, Department of Integral Dental Clinics, University Center of Health Sciences, University of Guadalajara (CUCS-UdeG), Guadalajara 44340, Jalisco, Mexico.
Seyed Ali MosaddadDepartment of Research Analytics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.ORCID https://orcid.org/0000-0001-6963-8289
Artak HeboyanDepartment of Prosthodontics, Faculty of Stomatology, Yerevan State Medical University After Mkhitar Heratsi, Str. Koryun 2, Yerevan 0025, Armenia.ORCID https://orcid.org/0000-0001-8329-3205

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Toll-like receptors (TLR2 and TLR4) are crucial in the detection of pathogen-associated molecular patterns (PAMPs) during periodontitis, resulting in exacerbated production of proinflammatory cytokines and ultimately tissue damage and bone loss associated with this periodontal disease. This systematic review and meta-analysis aimed to systematically analyze and quantify the differences between TLR2 and TLR4 levels in the saliva and plasma of individuals with chronic periodontitis (CP) and systemically and periodontally healthy subjects (SPHS). The databases consulted were Scopus, Web of Science, and PubMed from 2011 to 2024 to locate cross-sectional studies that measured TLR2 and TLR4 levels. Studies selected were human research articles published in English, evaluating these biomarkers through ELISA. Data were extracted, and the quality of studies was appraised using the Joanna Briggs Institute (JBI) tool for observational studies. Meta-analyses were executed using STATA V.15 (StataCorp LP, College Station, Texas) employing fixed or random-effects models based on the degree of heterogeneity using I

Indexed as

biomarkersperiodontitisplasmasalivaTLR2TLR4

Identifiers

PMID40371381
PMCPMC12074830

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.