ArticleFrontiers in public health2025
Investigation of the association between the triglyceride-glucose index and the incidence of frailty among middle-aged and older adults: evidence from the China health and retirement longitudinal study.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Association between body roundness index and frailty among middle aged and older adults in China.Scientific reports · 2026Article
- Triglyceride-glucose-related indices and cardiovascular outcomes in individuals with pre-frailty or frailty: insights from a prospective cohort analysis using UK Biobank data.Cardiovascular diabetology · 2026Article
- Association between different dimensions of C-reactive protein-triglyceride-glucose index and the incidence of frailty in middle-aged and elderly adults in China: a nationwide prospective cohort study.Lipids in health and disease · 2026Article
- Association of C-reactive protein-triglyceride-glucose index with all-cause and cardiovascular mortality in postmenopausal women.Przeglad menopauzalny = Menopause review · 2025Article
- Identifying Frailty Risk in Older Adults: The Predictive Value of Functional Tests and Center-of-Pressure-Based Postural Metrics.Journal of clinical medicine · 2025Article
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Authors and funding
5 authors.
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Abstract
Aim: Limited researches have investigated the association between the Triglyceride-glucose index (TyG) and frailty vulnerability in middle-aged and older Chinese populations. This study aims to strengthen the scientific foundation for frailty prevention and management by analyzing the correlation between TyG and frailty, ultimately providing more targeted intervention strategies. Methods: This study included middle-aged and older individuals who participated in the China Health and Retirement Longitudinal Study (CHARLS) from 2015. A multiple logistic regression model was constructed to assess the correlation between the TyG index and frailty. Additionally, restricted cubic spline (RCS) analysis was employed to evaluate the dose-response correlation between the two variables. Results: Among the 3,978 participants included in the study, 667 individuals (16.8%) were identified with frailty. After adjusting for multiple factors in a logistic regression model, it was determined that individuals in the highest quartile group of the TyG index had a 1.43 times higher risk of frailty compared to those in the lowest quartile group (OR = 1.43, 95% CI: 1.10 ~ 1.85, Conclusion: Research has shown a significant positive linear relationship between an increased TyG index and a higher prevalence of frailty in middle-aged and older individuals. Elevated TyG index levels could signal an increased vulnerability to frailty among individuals.
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