Evidence map›Paper›PMID 40371274›Full record

ArticleFrontiers in public health2025

Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and sarcopenia: evidence from CHARLS.

Changbo Sun, Honggang Jiang, Hongmei Zhu, Zhen Luo, Shiyi Wang

Abstract read
In one paragraph

Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Changbo SunDepartment of Gastroenterology, Ningbo Hospital of Traditional Chinese Medicine, Affiliated With Zhejiang Chinese Medical University, Ningbo, China.
Honggang JiangDepartment of Gastroenterology, Ningbo Hospital of Traditional Chinese Medicine, Affiliated With Zhejiang Chinese Medical University, Ningbo, China.
Hongmei ZhuDepartment of Gastroenterology, Ningbo Hospital of Traditional Chinese Medicine, Affiliated With Zhejiang Chinese Medical University, Ningbo, China.
Zhen LuoDepartment of Gastroenterology, Ningbo Hospital of Traditional Chinese Medicine, Affiliated With Zhejiang Chinese Medical University, Ningbo, China.
Shiyi WangDepartment of Gastroenterology, Ningbo Hospital of Traditional Chinese Medicine, Affiliated With Zhejiang Chinese Medical University, Ningbo, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Recent studies have highlighted an association between lipid disorders and sarcopenia. The role of the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) has not been explored among Chinese adults. This study aimed to investigate the association between the NHHR and incident sarcopenia in the Chinese population. Methods: The study included a total of 4,046 participants aged 50 years and older without a history of sarcopenia, from the China Health and Retirement Longitudinal Study (CHARLS). A multivariate logistic regression model and a restricted cubic spline model were used to investigate the association between NHHR and sarcopenia. Subgroup and sensitivity analyses were conducted to assess the robustness of the findings. Results: A total of 309 (7.6%) participants were newly diagnosed with sarcopenia in the 2015 wave. Participants in the highest NHHR quartile (≥3.99) had a significantly lower adjusted odds ratio for sarcopenia (OR = 0.40; 95% CI, 0.280.58; Conclusion: There is an inverse relationship between NHHR and sarcopenia risk in the Chinese population. A higher NHHR is associated with a lower risk of sarcopenia below the inflection point, beyond which NHHR is no longer significantly associated with sarcopenia risk.

Indexed as

CholesterolCholesterol, HDLSarcopeniaAgedChinaFemaleHumansLongitudinal StudiesMaleMiddle AgedRisk FactorsCholesterolCholesterol, HDLChinese populationdyslipidemialipid metabolismNHHRsarcopenia

Identifiers

PMID40371274
PMCPMC12074908

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.