Evidence map›Paper›PMID 40371216›Full record

Trial reportJournal of nutritional science2025

Effect of vitamin B1 supplementation on bone turnover markers in adults: an exploratory single-arm pilot study.

Akinori Hara, Chie Takazawa, Hiromasa Tsujiguchi, Jiaye Zhao, Masaharu Nakamura, Tomoko Kasahara, Yukari Shimizu, Hiroyuki Nakamura

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of nutritional science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Akinori HaraDepartment of Hygiene and Public Health, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan.ORCID https://orcid.org/0000-0002-0399-1474
Chie TakazawaDepartment of Hygiene and Public Health, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan.
Hiromasa TsujiguchiDepartment of Hygiene and Public Health, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan.ORCID https://orcid.org/0000-0001-7511-0165
Jiaye ZhaoDepartment of Hygiene and Public Health, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan.
Masaharu NakamuraDepartment of Hygiene and Public Health, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan.
Tomoko KasaharaDepartment of Hygiene and Public Health, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan.
Yukari ShimizuDepartment of Nursing, Faculty of Health Sciences, Komatsu University, Komatsu, Ishikawa, Japan.
Hiroyuki NakamuraDepartment of Hygiene and Public Health, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although B vitamins have been shown to play beneficial roles in bone health, the effects of vitamin B1 in humans are still unclear. This study aimed to investigate the effects of vitamin B1 supplementation on middle-aged and older adults. This single-armed trial study included community-dwelling adults in Japan and used a pre- and post-test design. The participants were given 28.0 mg of vitamin B1 supplementation per day for 1 month in addition to their daily usual diet. The effect of this treatment on bone turnover markers and metabolism was evaluated at baseline and after 1 month. Forty-two participants were enrolled (mean age, 58.6 ± 10.4 years; 36 women). The vitamin B1 levels in whole blood increased significantly from baseline after vitamin B1 supplementation. The level of serum tartrate-resistant acid phosphatase 5b (TRACP 5b), a bone resorption marker, reduced significantly (378 ± 135 vs. 335 ± 120 mU/dL, p < 0.001), while the level of N-terminal propeptide of type I procollagen (P1NP), a marker specific to bone formation, did not change. Moreover, the serum phosphorus and parathyroid hormone (PTH) concentrations did not change, whereas the corrected serum calcium concentrations increased and vitamin D concentrations decreased. The serum TRACP 5b levels decreased after vitamin B1 supplementation in the middle-aged and older adults. Further definitive trials are needed to determine the efficacy of vitamin B1 in improving bone health.

Indexed as

Bone and BonesBone RemodelingDietary SupplementsThiamineVitamin B ComplexAcid PhosphataseAgedBiomarkersBone ResorptionCalciumFemaleHumansJapanMaleMiddle AgedParathyroid HormoneAcid PhosphataseACP5 protein, humanBiomarkersCalciumParathyroid HormonePeptide FragmentsPhosphorusProcollagenprocollagen Type I N-terminal peptideTartrate-Resistant Acid PhosphataseThiamineVitamin B ComplexVitamin D,25(OH)D, 25-hydroxyvitamin D,BMD, bone mineral density,BMI, body mass index,eGFR, estimated glomerular filtration rateNutritionOsteoclastOsteoporosis,P1NP, N-terminal propeptide of type I procollagenPrevention,PTH, parathyroid hormoneThiamine,TRACP, tartrate-resistant acid phosphatase

Identifiers

PMID40371216
PMCPMC12075007

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.