Evidence map›Paper›PMID 40371152›Full record

ArticleAmerican journal of cancer research2025

Identification of novel NUP98::RARA fusion transcripts in acute promyelocytic leukemia with i(17)(q10) abnormality.

Jifang Tu, Huanping Wang, Yungui Wang, Hongyan Tong

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PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. BipartiteHaematologica · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jifang TuDepartment of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou, Zhejiang, China.
Huanping WangDepartment of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou, Zhejiang, China.
Yungui WangDepartment of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou, Zhejiang, China.
Hongyan TongDepartment of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute promyelocytic leukemia (APL) is one subtype of acute myeloid leukemia (AML) primarily associated with the typical fusion gene PML::RARA/t(15;17). A small percentage of APL cases are caused by atypical gene transcript variants lacking the PML::RARA. We report one case with two novel NUP98::RARA fusion transcripts in APL lacking the fusion gene PML::RARA/t(15;17). These NUP98::RARA fusion transcripts were identified using next-generation sequencing (NGS), which were confirmed by Sanger sequencing. One of the transcripts differs from the previously reported transcript in terms of break sites and transcript length, which identified as subtype of NUP98::RARA fusion transcript. The other one is the same as previously reported, demonstrating reproducible abnormality of this fusion gene. The patient was treated with all-trans retinoic acid (ATRA), realgar-Indigo naturalis formula (RIF) and chemotherapy. According to the published paper, this is the second report of NUP98::RARA fusion transcript in APL. It is also the first variant APL with der(11)(p15)t(11;17)(p15;q21) and i(17)(q10) chromosome abnormalities. Therefore, we compared and summarized these two cases.

Indexed as

APLi(17)(q10)NUP98::RARAt(11;17)(p15;q21)

Identifiers

PMID40371152
PMCPMC12070106

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