ArticleAmerican journal of cancer research2025
Effect of gamma knife stereotactic radiotherapy on the hematological system in patients with advanced lung cancer and its therapeutic effect.
Article in American journal of cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo evaluate the influence of Gamma Knife stereotactic body radiotherapy (SBRT) on the hematological system in patients with advanced lung cancer and to assess its clinical outcomes.
methodsA retrospective analysis was conducted on the clinical data of 192 patients with advanced lung cancer. 108 patients who received conventional radiotherapy were included in the control group, and the rest 84 patients who received Gamma Knife SBRT were included in the experimental group. Treatment outcomes, disease progression one year after radiotherapy, blood cell counts, coagulation function, quality of survival scores, and adverse reactions were compared between the two groups.
resultsThe experimental group exhibited a significantly higher disease control rate (DCR) and objective response rate (ORR) compared to the control group (both
conclusionCompared to traditional radiotherapy, Gamma Knife SBRT has a less detrimental impact on the blood cell level, morphology, and coagulation function in patients with moderate to advanced lung cancer. It also improves patients' quality of survival with fewer adverse reactions and better disease control. These findings suggest that Gamma Knife SBRT is a promising treatment option and warrants further exploration and adoption in clinical practice.
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