Evidence map›Paper›PMID 40371110›Full record

ArticleFrontiers in microbiology2025

Emergence of an XDR

Yinfei Fang, Xiangchen Li, Zhaoxia Wu, Yongjin Fang, Yeping Wang, Xiaobing Li, Lihong Bu, Keqiang Chen, Kai Shen, Yongjun Ma and 1 more

Abstract read
In one paragraph

Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Emergence ofCurrent research in microbial sciences · 2025
    Article
  5. Extended-Spectrum β-Lactamase-ProducingInfection and drug resistance · 2025
    Article
  6. Mobile genetic elements in shapingFrontiers in microbiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yinfei Fang *Department of Clinical Laboratory, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China.
Xiangchen Li *Jiaxing Key Laboratory of Clinical Laboratory Diagnostics and Translational Research, Affiliated Hospital of Jiaxing University, Jiaxing, China.
Zhaoxia Wu *Department of Clinical Laboratory, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China.
Yongjin FangDepartment of Otolaryngology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China.
Yeping WangDepartment of Pediatrics, Jinhua Women's and Children's Hospital, Jinhua, China.
Xiaobing LiDepartment of Pediatrics, Jinhua Women's and Children's Hospital, Jinhua, China.
Lihong BuDepartment of Clinical Laboratory, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China.
Keqiang ChenDepartment of Clinical Laboratory, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China.
Kai ShenDepartment of Clinical Laboratory, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China.
Yongjun MaDepartment of Clinical Laboratory, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China.
Mingjuan WuDepartment of Health Management, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The rapid emergence of antimicrobial resistance (AMR) in Methods: The KP09 strain, isolated from a clinical sample, was subjected to antimicrobial susceptibility testing and conjugation experiments. Whole-genome sequencing with both long- and short-read methods facilitated hybrid assembly for complete genome reconstruction. Bioinformatics analyses identified resistance genes, plasmid structures, and sequence types (STs), whereas comparative genomic analysis elucidated the context and dissemination mechanisms of resistance determinants. Results: KP09 exhibited broad-spectrum resistance to carbapenems, colistin, eravacycline, and tigecycline, and only remained susceptible to cefiderocol. The conjugation experiments successfully produced four transconjugants, each carrying specific plasmids: JKP09-1 harbored the Conclusion: This study provides critical information on the genetic mechanisms that drive AMR in

Indexed as

antimicrobial resistance (AMR)extensively drug-resistant (XDR)genomic analysisIncFIA/IncFII/IncQ1 hybrid plasmidKlebsiella pneumoniae

Identifiers

PMID40371110
PMCPMC12075367

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.