Evidence map›Paper›PMID 40371086›Full record

ArticleFrontiers in neurology2025

Assessment of causality association between serum adiponectin levels and the risk of Alzheimer's disease and Parkinson's disease: a Mendelian randomization study.

Jiali Lin, Langhuan Lei, Qiuyu Liang, Xiaozhi Huang, Yanping Ding, Liuxian Pan, Jianrong Yang, Wei Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jiali Lin *Research Center of Health Management, Guangxi Zhuang Autonomous Region People's Hospital, Guangxi Academy of Medical Sciences, Nanning, China.
Langhuan Lei *Research Center of Health Management, Guangxi Zhuang Autonomous Region People's Hospital, Guangxi Academy of Medical Sciences, Nanning, China.
Qiuyu Liang *Research Center of Health Management, Guangxi Zhuang Autonomous Region People's Hospital, Guangxi Academy of Medical Sciences, Nanning, China.
Xiaozhi HuangDepartment of Health Management, Guangxi Zhuang Autonomous Region People's Hospital, Guangxi Academy of Medical Sciences, Nanning, China.
Yanping DingDepartment of Health Management, Guangxi Zhuang Autonomous Region People's Hospital, Guangxi Academy of Medical Sciences, Nanning, China.
Liuxian PanDepartment of Health Management, Guangxi Zhuang Autonomous Region People's Hospital, Guangxi Academy of Medical Sciences, Nanning, China.
Jianrong YangResearch Center of Health Management, Guangxi Zhuang Autonomous Region People's Hospital, Guangxi Academy of Medical Sciences, Nanning, China.
Wei LiResearch Center of Health Management, Guangxi Zhuang Autonomous Region People's Hospital, Guangxi Academy of Medical Sciences, Nanning, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Until recently, the association between circulating adiponectin (ADPN) levels and the risk of Alzheimer's disease (AD) and Parkinson's disease (PD) remained unclear. Methods: We utilized public data from the IEU GWAS database to conduct a two-sample bidirectional Mendelian randomization (MR) analysis and multiple sensitivity analyses. The MR analysis was performed using the aggregated data, with the genetic risk score (GRS) serving as an instrumental variable. Results: The MR analyses revealed no significant causal association between genetically determined ADPN levels and the risk of AD (OR Conclusion: Our findings provide no evidence to substantiate a causal relationship between ADPN levels and the risk of AD and PD or vice versa. However, elevated levels of ADPN may correlate with lower levels of IL1β.

Indexed as

adiponectinAlzheimer’s diseaseMendelian randomizationneurodegenerative diseasesParkinson’s disease

Identifiers

PMID40371086
PMCPMC12075267

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.