Gliadin Encapsulated Procyanidolic Oligomers Nanoformulation: Aggrandized Antimicrobial, Antioxidant as Well as Anticancer Potential Makes it an Effective Therapeutic Modality for Lung Carcinoma.

Sant Lal, Monika Kataria, Ruma Rani, Neeraj Dilbaghi

Abstract read

In one paragraph

Article in Indian journal of microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Sant LalDepartment of Biotechnology, Guru Jambheshwar University of Science and Technology, Hisar, Haryana 125001 India.

Monika KatariaDepartment of Biotechnology, Guru Jambheshwar University of Science and Technology, Hisar, Haryana 125001 India.

Ruma RaniICAR-National Research Centre On Equines, Hisar, Haryana 125001 India.

Neeraj DilbaghiDepartment of Biotechnology, Guru Jambheshwar University of Science and Technology, Hisar, Haryana 125001 India.ORCID 0000-0002-3503-4206

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung cancer is responsible for highest mortality rates among both men and women globally. There is a need of effective and safe treatment modality that specifically targets cancer cells and doesn't not harm healthy cells. Procyanidolic oligomers (PCOs) is a natural antioxidant found in grape seed, acts as medicament for the treatment of various disease which are linked with oxidative stress specifically cancer. The aim of the current study was to synthesize highly stable gliadin encapsulated PCOs nanoformulation (PCO-NF). The PCOs nanoformulation (PCO-NF) showed spherical morphology (17.18-76.56 nm) with an average particle size 49.37 ± 22.17 nm diameter in electron microscopy and stable zeta potential i.e. - 23.1 mV and low polydispersity index i.e. 0.246 in dynamic light scattering (DLS). The therapeutic efficacy of PCO-NF has been evaluated through antioxidative, anticancer as well as antimicrobial studies. Antioxidant potency was assessed using DPPH scavenging assay and it was observed that IC

Indexed as

Anticancer activityAntimicrobial activityLung carcinomaProcyanidolic oligomers nanoformulation (PCO-NF)

Identifiers

PMID40371047

DOI10.1007/s12088-024-01380-w

PMCPMC12069783

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.