Evidence map›Paper›PMID 40371043›Full record

ArticleIndian journal of microbiology2025

Mucus-Penetrating PEGylated Nanoshuttle for Enhanced Drug Delivery and Healthcare Applications.

Anoothi Bain, Nupur Vasdev, Anuja Muley, Pinaki Sengupta, Rakesh Kumar Tekade

Abstract read
In one paragraph

Article in Indian journal of microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anoothi BainDepartment of Pharmaceuticals, Ministry of Chemicals and Fertilizers, National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A), An Institute of National Importance, Government of India, Palaj, Opp. Air Force Station, Gandhinagar, Gujarat 382355 India.
Nupur VasdevDepartment of Pharmaceuticals, Ministry of Chemicals and Fertilizers, National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A), An Institute of National Importance, Government of India, Palaj, Opp. Air Force Station, Gandhinagar, Gujarat 382355 India.
Anuja MuleyDepartment of Pharmaceuticals, Ministry of Chemicals and Fertilizers, National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A), An Institute of National Importance, Government of India, Palaj, Opp. Air Force Station, Gandhinagar, Gujarat 382355 India.
Pinaki SenguptaDepartment of Pharmaceuticals, Ministry of Chemicals and Fertilizers, National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A), An Institute of National Importance, Government of India, Palaj, Opp. Air Force Station, Gandhinagar, Gujarat 382355 India.
Rakesh Kumar TekadeDepartment of Pharmaceuticals, Ministry of Chemicals and Fertilizers, National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A), An Institute of National Importance, Government of India, Palaj, Opp. Air Force Station, Gandhinagar, Gujarat 382355 India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The delivery of therapeutic agents across mucosal barriers represents a significant challenge in drug delivery due to the protective nature of mucus layers that line various human body cavities. These barriers are challenging in treating ailments where targeted delivery could substantially improve therapeutic outcomes. Conventional drug delivery systems often face limitations in penetrating the mucus layer, leading to reduced efficacy, lower bioavailability, and increased need for higher dosages, which can cause adverse side effects. This manuscript introduces Mucus-penetrating PEGylated Nanoshuttles (MPNS) as a pioneering strategy designed to overcome these challenges. MPPNSs are engineered with specific surface properties and sizes that allow them to traverse the mucus barrier efficiently without becoming trapped, providing a promising solution for enhanced drug delivery to mucosal tissue.

Indexed as

Mucus barrierMucus penetrating nanoshuttlePEGylationStrategies for mucus penetration

Identifiers

PMID40371043
PMCPMC12069781

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.