ArticleJournal of biomedical optics2025
Quantitative measurement of tympanic membrane structure and symmetry with optical coherence tomography in normal human subjects.
Article in Journal of biomedical optics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Parametric Physically Grounded Rendering of Otoscopic Morphology for Synthetic Medical Image Generation.Journal of imaging · 2026Article
- Progression of Vestibular Deficits Following Moderate-Intensity Blast Overpressure in Rats.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
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Authors and funding
5 authors.
Funding
Abstract
Significance: Early detection of ear pathology is essential for preventing hearing loss, yet the sensitivity of otoscopic examinations by primary care providers during annual physicals remains low. Optical coherence tomography (OCT) offers a promising alternative for detailed imaging of the tympanic membrane (TM) and middle ear (ME), providing the potential for early identification of ear disease. Aim: We aim to develop a quantitative method for assessing symmetry between the right and left ears and to establish a baseline for this approach in normal subjects. Approach: Volumetric OCT images were acquired from 12 normal subjects using a custom hand-held OCT otoscope. A volume registration and fusion method was applied to expand the TM field of view, followed by TM thickness measurement and generation of 3D thickness maps. The symmetry between left and right TMs was quantitatively analyzed using the Dice similarity coefficient. Results: The average TM thickness was measured as Conclusions: OCT imaging enables quantitative assessment of TM thickness and symmetry, offering a baseline for identifying early ear pathologies.
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