Evidence map›Paper›PMID 40370999›Full record

ArticleJournal of biomedical optics2025

Resorbable optical fibers for interstitial photodynamic therapy-assessment of photosensitizer spatial distribution in tumors.

Jawad T Pandayil, Stefan Šušnjar, Muhammad Daniyal Ghauri, Sanathana Konugolu Venkata Sekar, Johannes Swartling, Davide Janner, Nadia G Boetti, Nina Reistad

Abstract read
In one paragraph

Article in Journal of biomedical optics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Advancements and emerging trends in photodynamic therapy: innovations in cancer treatment and beyond.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jawad T PandayilFondazione LINKS-Leading Innovation and Knowledge for Society, Torino, Italy.ORCID 0009-0007-7007-0003
Stefan ŠušnjarLund University, Department of Physics, Lund, Sweden.ORCID 0000-0001-7925-0624
Muhammad Daniyal GhauriTyndall National Institute, Cork, Ireland.ORCID 0000-0001-7667-7702
Sanathana Konugolu Venkata SekarTyndall National Institute, Cork, Ireland.ORCID 0000-0003-0912-1282
Johannes SwartlingSpectraCure AB, Lund, Sweden.ORCID 0009-0001-2161-5341
Davide JannerPolitecnico di Torino, Dipartimento di Scienza Applicata e Tecnologia (DISAT) and RU INSTM, Torino, Italy.ORCID 0000-0001-7954-979X
Nadia G BoettiFondazione LINKS-Leading Innovation and Knowledge for Society, Torino, Italy.ORCID 0000-0002-5269-2390
Nina ReistadLund University, Department of Physics, Lund, Sweden.ORCID 0000-0002-7025-5725

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Significance: Optical-quality bioresorbable implants, which gradually dissolve within the body, are gaining increasing interest due to their potential to eliminate the need for revision surgeries. These implants show significant promise in treating deep-seated tumors in high-risk areas, such as the brain, and offer extended capabilities for monitoring interstitial physiological parameters or pharmacokinetics through photonic technologies. Aim: A proof-of-principle validation has been conducted on calcium phosphate glass (CPG)-based bioresorbable optical fibers to assess their capability to monitor the spatial distribution of photosensitizing (PS) drugs in tumors-an essential parameter to optimize for enhanced treatment outcomes in photodynamic therapy (PDT). Approach: Results: The reconstructed drug distribution with bioresorbable fibers agreed with that obtained using the same system with standard silica fibers. Conclusions: We reveal the potential of further exploring CPG bioresorbable optical fibers for interstitial PDT.

Indexed as

Absorbable ImplantsNeoplasmsOptical FibersPhotochemotherapyPhotosensitizing AgentsCalcium PhosphatesEquipment DesignHumansOptical ImagingPhantoms, ImagingCalcium PhosphatesPhotosensitizing Agentsbioresorbable photonicsdiffuse optical tomographyfluorescenceoptical fibersphotodynamic therapyphotosensitizer distribution

Identifiers

PMID40370999
PMCPMC12076020

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.