ArticleJournal of biomedical optics2025
Motion-based dynamic light delivery to minimize laser-related thermal damage while preserving photoacoustic image quality.
Article in Journal of biomedical optics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Review
- Pigmentation-dependent skin injury thresholds with nanosecond single-pulse laser exposure.Journal of biomedical optics · 2026Article
- A numerical study on the effect of laser therapy against port-wine stain by administering artificial red blood cells.Lasers in medical science · 2026Article
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Significance: Photoacoustic imaging has the potential to be integrated into surgical guidance systems. However, biosafety from prolonged laser exposure can limit the maximization of signal-to-noise ratios. Although cooling strategies can potentially mitigate thermal impact, the associated adverse effects necessitate an alternative strategy. Aim: We introduce a dynamic light delivery strategy that displaces a light source in a controlled manner during photoacoustic imaging, which is expected to both minimize laser-related thermal damage and maintain the image quality achievable with stationary light delivery. Approach: Monte Carlo simulations were performed to determine the impact of light source displacement on local energy density. A dynamic light delivery device was designed, prototyped, and evaluated with an experimental phantom to determine image quality. To assess potential laser-related thermal damage, Results: Energy densities at the simulated tissue surface were 1.85 lower with dynamic rather than stationary light delivery. As target depth was varied from 14 to 53 mm, the median signal-to-noise and generalized contrast-to-noise ratios ranged 24.60 to 38.76 and 0.96 to 1.00, respectively, with stationary light delivery and 23.06 to 37.47 and 0.96 to 1.00, respectively, with dynamic light delivery, with no statistically significant differences between light delivery approaches ( Conclusions: Dynamic light delivery is a promising approach to mitigate potential laser-related damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.