Evidence map›Paper›PMID 40370956›Full record

ArticlebioRxiv : the preprint server for biology2025

An autism spectrum disorder mutation in Topoisomerase 3β causes accumulation of covalent mRNA intermediates by disrupting metal binding within the zinc finger domain.

Julia E Warrick, Durga Attili, Trevor van Eeuwen, Benjamin Pastore, Sarah E Hoffmann-Weitsman, Nicholas C Forsyth, Wen Tang, Sami J Barmada, Michael G Kearse

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Julia E WarrickDepartment of Biological Chemistry and Pharmacology, Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA.
Durga AttiliDepartment of Neurology, Center for RNA Biomedicine, University of Michigan, Ann Arbor, MI 48109, USA.
Trevor van EeuwenLaboratory of Cellular and Structural Biology, The Rockefeller University, New York, NY, 10065 USA.
Benjamin PastoreDepartment of Biological Chemistry and Pharmacology, Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA.
Sarah E Hoffmann-WeitsmanDepartment of Biological Chemistry and Pharmacology, Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA.
Nicholas C ForsythDepartment of Biological Chemistry and Pharmacology, Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA.
Wen TangDepartment of Biological Chemistry and Pharmacology, Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA.
Sami J BarmadaDepartment of Neurology, Center for RNA Biomedicine, University of Michigan, Ann Arbor, MI 48109, USA.
Michael G KearseDepartment of Biological Chemistry and Pharmacology, Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA.

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Daniel G. Stover · 1985 to 2026
$132.3M
RNA decay in amyotrophic lateral sclerosis and frontotemporal lobar degenerationR01NS097542 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BARMADA, SAMI · 2016 to 2025
$3.8M
Heritable macromolecules in C. elegans germ granulesR35GM142580 · NIGMS · OHIO STATE UNIVERSITY · PI TANG, WEN · 2021 to 2025
$2.0M
Atypical TDP43 isoforrms driving neurodegeneration in FTD/ALSR01NS113943 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BARMADA, SAMI · 2020 to 2024
$1.9M
Non-canonical mechanisms of translation initiation and regulationR35GM146924 · NIGMS · OHIO STATE UNIVERSITY · PI Michael G. Kearse · 2022 to 2026
$1.9M
Elucidating the Mechanisms Underlying Mutant TDP43-induced NeurodegenerationK08NS072233 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BARMADA, SAMI · 2011 to 2015
$879k
Spatiotemporal analysis of TDP-43 toxicity and endolysosomal turnover mechanismsR56NS128110 · NINDS · UNIVERSITY OF ARIZONA · PI BARMADA, SAMI, BUCHAN, JOHN ROSS · 2022 to 2022
$393k
Inductively Coupled Plasma Mass Spectrometer for High Sensitivity Elemental AnalysisS10OD028492 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI RALLE, MARTINA · 2021 to 2021
$336k
NCI NIH HHS P30 CA016058NIGMS NIH HHS R35 GM142580NIGMS NIH HHS R35 GM146924NIH HHS S10 OD028492NINDS NIH HHS K08 NS072233NINDS NIH HHS R01 NS097542NINDS NIH HHS R01 NS113943NINDS NIH HHS R56 NS128110
6 · The paper itself

Abstract

The loss and mutation of Topoisomerase 3β (TOP3B), the only known eukaryotic topoisomerase with the ability to catalyze RNA strand passage reactions, is linked to schizophrenia, autism, and intellectual disability. Uniquely, TOP3B primarily localizes to the cytoplasm and has been shown to regulate translation and stability of a subset of mRNA transcripts. Three neurological disease-linked

Identifiers

PMID40370956
PMCPMC12077875

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.