ReviewCureus2025
Co-crystallization in Antiepileptic Drugs: A Path Toward Better Therapeutic Outcomes.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pharmaceutical cocrystals are highly valued in drug development as they can enhance active pharmaceutical ingredients (APIs)' physicochemical characteristics without changing their chemical structure. This is especially important for biopharmaceutical classification system (BCS) class II and IV drugs, which have poor water solubility, resulting in low bioavailability. Co-crystallization is the process of forming a crystalline solid where the API and a co-former are combined in a specified stoichiometric proportion within a crystal lattice, mainly stabilized by non-covalent interactions. This method can enhance properties like stability, dissolution rate, solubility, compressibility, and powder flowability and pharmacokinetics, resulting in an improved drug delivery system and therapeutic effectiveness. Pharmaceutical antiepileptic drugs (AEDs) are the main focus of this review. Pharmaceutical characteristics, conventional and advanced cocrystal generation, and assessment techniques, as well as recent developments related to cocrystals, may suggest perception for cocrystal potential, design approaches, and regulatory aspects. The study's overall finding emphasizes the growth of co-crystallization as a significant technique to enhance the drug's performance and also demonstrates its potential as a significant technique in the AED category and its future application.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.