ReviewCureus2025
Harnessing the Underutilized Potential of Lens Capsule Transplantation in Ophthalmology: A Narrative Review of Current Applications and Future Directions.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Innovative Applications of Nanomaterials in the Diagnosis and Treatment of Ocular Diseases: Targeted Delivery, Intelligent Therapy, Diagnostic Breakthroughs, and Synergistic Strategies with Stem Cells and Biomaterials.International journal of nanomedicine · 2026Review
- Emerging Innovations in the Treatment of Fuchs Endothelial Corneal Dystrophy: A Narrative Review.Medical sciences (Basel, Switzerland) · 2025Review
- Human Omental Mesothelial Cells Exhibit a Corneal Endothelial-Like Cell Phenotype for Tissue Engineering of a Corneal Endothelium Biomimetic.Investigative ophthalmology & visual science · 2025Article
- Ex Vivo Microsuturing of the Human Anterior Lens Capsule Using 10-0 Sutures: A Technical Feasibility Report.Cureus · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human lens capsule is a transparent and durable basement membrane routinely discarded during cataract surgery, exhibiting unique biochemical, biomechanical, and immunologic properties. This narrative review discusses validated ophthalmic applications across corneal, retinal, and glaucoma filtration surgeries. It emphasizes the capsule's emerging role as a tissue-engineering scaffold for cultivating corneal endothelial cells, limbal epithelial stem cells, and retinal pigment epithelial cells, demonstrating significant promise in regenerative ophthalmology. However, variability in harvesting techniques, small graft sizes, and limited long-term clinical data currently hinder its broader clinical implementation. Future directions highlight the necessity of standardizing capsule harvesting and preservation protocols, potentially in collaboration with eye banks, to enhance accessibility and utility. Additionally, this review explores speculative applications, including encapsulation devices for drug and cell delivery, ultraviolet cross-linking for keratoconus management, and novel scaffolds for optic nerve regeneration and retinal transplantation. While preliminary evidence strongly supports the capsule's versatility, rigorous clinical trials and comparative analyses remain essential to establish long-term safety, efficacy, and optimal surgical integration. Ultimately, harnessing this naturally available biomaterial represents a meaningful advancement in ophthalmology, opening new horizons for future research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.