ArticleClinical case reports2025
IL-8 and IL-1β in the Cerebrospinal Fluid of Patient With Creutzfeldt-Jakob Disease: A Case Report.
Article in Clinical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Therapeutic strategies in prion disease: current evidence, translational challenges, and emerging directions.Frontiers in neuroscience · 2026Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammatory cytokines play a crucial role in Creutzfeldt-jakob disease (CJD). We examined inflammatory cytokine levels in both blood and CSF in a CJD patient and an epileptic encephalopathy as a control case. Results showed that IL-6, IL-8, IL-1β, and TNF-α levels were elevated in blood, but only IL-8 and IL-1β levels, especially IL-8, were significantly elevated in Cerebrospinal fluid (CSF). This suggests that IL-8 and IL-1β are closely related to cognitive impairment and blood-brain barrier (BBB) damage in CJD, and IL-8 might be a key target in early cognitive impairment in CJD.
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