Evidence map›Paper›PMID 40370748›Full record

ArticleFrontiers in aging neuroscience2025

Amyloid-beta peptide toxicity in the aged brain is a one-way journey into Alzheimer's disease.

Georgia Culley, Alexandre Henriques, Delphine Hardy, Alexandre Wojcinski, Adrien Chabert, Bilal El Waly, Philippe Poindron, Noelle Callizot

Abstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Georgia Culley *Neuro-Sys Vivo, Gardanne, France.
Alexandre Henriques *Neuro-Sys Vivo, Gardanne, France.
Delphine HardyNeuro-Sys Vivo, Gardanne, France.
Alexandre WojcinskiNeuro-Sys Vivo, Gardanne, France.
Adrien ChabertNeuro-Sys Vivo, Gardanne, France.
Bilal El WalyNeuro-Sys Vivo, Gardanne, France.
Philippe PoindronNeuro-Sys Vivo, Gardanne, France.
Noelle CallizotNeuro-Sys Vivo, Gardanne, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging is the primary risk factor for Alzheimer's disease (AD), and the aging brain shares many characteristics with the early stages of AD. This study investigates the interplay between aging and amyloid-beta (Aβ) induced pathology. We developed an AD-like

Indexed as

agingAlzheimer’samyloid toxicityneurodegenerationneuroinflammationoligomersspreadingtau

Identifiers

PMID40370748
PMCPMC12075133

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.