ArticleFrontiers in medicine2025
Endoscopic ultrasound with submucosal saline injection improves the accuracy of T1a and T1b staging in superficial esophageal squamous cell carcinoma.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Boundary-guided VMUNet for atrophic gastritis lesion segmentation in magnifying endoscopy with narrow-band imaging.Frontiers in medicine · 2026Article
- Submucosal saline injection-assisted endoscopic ultrasonography for accurate layer identification of a rectal subepithelial lesion.Endoscopy · 2025Article
- Endoscopic Ultrasound in Squamous Cell Esophageal Cancer: From Staging to Strategy-A Narrative Review.Diagnostics (Basel, Switzerland) · 2025Review
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Authors and funding
6 authors.
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Abstract
Background: Endoscopic ultrasound (EUS) is important for diagnosing and staging esophageal cancer. However, substantial variability in the diagnostic and staging accuracy of EUS, especially in early-stage cancers, affects patients' treatment choices and quality of life. Aims: To explore whether conventional endoscopic ultrasonography (EUS-C) combined with submucosal saline injection (EUS-SSI) improves diagnostic accuracy in preoperative T1a and T1b staging in superficial esophageal squamous cell carcinoma (SESCC). Methods: Patients with SESCC first underwent EUS-C. Then, they received SSI and underwent a repeat EUS. The diagnostic accuracy of EUS-C and EUS-SSI was evaluated based on the final postoperative pathology results. Results: A total of 92 patients with endoscopically diagnosed SESCC were included in the study. Postoperative pathology confirmed superficial SESCC in all patients (T1a stage, Conclusion: EUS-SSI differentiates between T1a and T1b stages of superficial SESCC with better diagnostic accuracy than EUS-C, thereby reducing the rate of over-staging.
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