ArticleFrontiers in genetics2025
Genetic architecture of thermotolerance traits in beef cattle: a novel integration of SNP and breed-of-origin effects.
Article in Frontiers in genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Rising temperatures increasingly expose beef cattle to heat stress, reducing productivity and welfare, especially in tropical climates. Crossbreeding Methods: Phenotypes for short hair length (SHL, undercoat) and long hair length (LHL, topcoat), sweat gland area (SGA), and thermal stress slope (TSS), a measure of body temperature fluctuations under heat stress, were collected from 3,962 crossbred Angus-Brahman heifers. Heifers were genotyped, and breed-of-origin (BOA) for each marker was determined using LAMP-LD. Genome-wide association studies were conducted using SNP-only, BOA-only, and integrated SNP + BOA models to identify quantitative trait loci (QTLs) associated with thermotolerance traits. Genes in QTL regions were used for functional enrichment analysis using Gene Ontology (GO) and KEGG pathways. Results: Significant QTLs for SHL and LHL were identified on BTA20, overlapping the Conclusion: This study demonstrates the value of integrating BOA with SNP-based models to uncover the genetic architecture of thermotolerance traits in beef cattle. By better capturing breed-specific contributions, these findings enhance our understanding of thermoregulation and provide actionable insights for improving heat resilience in cattle.
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