Evidence map›Paper›PMID 40370694›Full record

ArticleCase reports in dentistry2025

Management of Medication-Related Osteonecrosis of the Jaw in Multiple Myeloma Patients With Pentoxifylline and Tocopherol: Case Reports.

Adepitan A Owosho, Katherine A DeColibus, Layne C Levy, Osariemen Okhuaihesuyi

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Adepitan A OwoshoDepartment of Diagnostic Sciences, College of Dentistry, The University of Tennessee Health Sciences Center, Memphis, Tennessee, USA.ORCID https://orcid.org/0009-0005-8290-6723
Katherine A DeColibusDepartment of Diagnostic Sciences, College of Dentistry, The University of Tennessee Health Sciences Center, Memphis, Tennessee, USA.
Layne C LevyDepartment of Diagnostic Sciences, College of Dentistry, The University of Tennessee Health Sciences Center, Memphis, Tennessee, USA.
Osariemen OkhuaihesuyiMissouri School of Dentistry and Oral Health, A. T. Still University, Kirksville, Missouri, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Medication-related osteonecrosis of the jaw (MRONJ) is a well-known side effect of bone-modifying agents such as antiresorptive medications including pamidronic and zoledronic acids (intravenous bisphosphonates) and denosumab (anti-RANK ligand humanized monoclonal antibody). The major risk factor for the precipitation of MRONJ in a patient taking antiresorptive medication is dentoalveolar trauma such as dental extractions. Management of MRONJ in oncology patients is exceptionally challenging. In this report, two multiple myeloma patients with longstanding advanced-stage MRONJ were successfully managed with combined pentoxifylline-tocopherol treatment pre- and postextraction/sequestrectomy. In conclusion, based on this report and other published reports, it appears that the use of combined pentoxifylline-tocopherol protocol in the management of MRONJ is effective.

Indexed as

BRONJdenosumabmedical managementMRONJoncologyzoledronic acid

Identifiers

PMID40370694
PMCPMC12077977

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