ArticleNature and science of sleep2025
Autonomic Nervous Regulation was Associated with Sleep Quality Among Peritoneal Dialysis Patients.
Article in Nature and science of sleep, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The issue of compromised sleep quality among patients with end-stage kidney disease (ESKD), particularly those undergoing peritoneal dialysis (PD), is notably pronounced. Dialysis patients exhibit significant alterations in cardiac autonomic nerve activity. However, the relationship between autonomic nervous system activity and sleep remains inadequately elucidated. Methods: This cross-sectional study enrolled adult maintenance PD patients in our center. The Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality. Heart rate variability (HRV) and Skin sympathetic nerve activity (SKNA) parameters were recorded to reflect autonerve activity responses or regulation capacity. Results: A total of 73 PD patients participated in this study, with a prevalence of poor sleep quality at 38.4%. Serum creatinine (1157.0±294.3 vs 969.6±353.4 mmHg, p = 0.022) and phosphorus levels (2.1±0.5 vs 1.7±0.5 mmHg, p = 0.002) were higher in the poor sleep quality group compared to the good group. Linear regression analyses indicated that PSQI scores were associated with SKNA (β, -2.54; 95% CI, -4.90 to -0.19; P=0.035), standard deviation of all sinus RR intervals (SDNN) (β, -0.05; 95% CI, -0.09 to -0.01; P=0.015), and SD2 (β, -0.04; 95% CI, -0.07 to -0.01; P=0.018). Conclusion: Poor sleep quality in PD patients may be associated with longer dialysis vintage, higher BMI, higher diastolic blood pressure, and higher level of serum uremic toxin, and affected by cardiac autonomic nerve function disorder.
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