Evidence map›Paper›PMID 40370604›Full record

ArticleRoyal Society open science2025

Synthesis and biological evaluation of esterified anti-inflammatory drugs with ethylene glycol linkers: cytotoxicity, anti-inflammatory and antioxidant properties.

Pascaline M Deussom, Monique Bassomo Ewonkem, Brice Enang, Michael H K Kamdem, Michel A Mbock, Marthe C D Fotsing, Derek T Ndinteh, Frederic N Njayou, Flavien A Toze

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Royal Society open science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Pascaline M DeussomDepartment of Chemistry, University of Douala, Douala, Cameroon.
Monique Bassomo EwonkemDepartment of Chemistry, University of Douala, Douala, Cameroon.ORCID https://orcid.org/0000-0003-2617-6672
Brice EnangDepartment of Biochemistry, University of Yaounde I Faculty of Sciences, Yaounde, Cameroon.
Michael H K KamdemDepartment of Chemical Sciences, University of Johannesburg - Doornfontein Campus, Doornfontein, South Africa.
Michel A MbockDepartment of Chemistry, University of Yaounde I Faculty of Sciences, Yaounde, Cameroon.
Marthe C D FotsingDepartment of Chemical Sciences, University of Johannesburg - Doornfontein Campus, Doornfontein, South Africa.
Derek T NdintehDepartment of Chemical Sciences, University of Johannesburg - Doornfontein Campus, Doornfontein, South Africa.
Frederic N NjayouDepartment of Biochemistry, University of Yaounde I Faculty of Sciences, Yaounde, Cameroon.
Flavien A TozeDepartment of Chemistry, University of Douala, Douala, Cameroon.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of multifunctional drugs from anti-inflammatory agents is a promising strategy for people with several inflammation-related comorbidities since such medicines could reduce complications, improve health outcomes and lower healthcare costs. In this study, esters of ibuprofen, cinnamic and salicylic acids were synthesized and characterized by spectroscopic methods, with six new compounds identified. Cytotoxicity and anti-inflammatory properties were assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium assay in mouse-derived peritoneal macrophages, which were obtained following an intraperitoneal injection of 0.5 ml of a 2% starch solution. All the tested compounds were safe up to 50% concentrations (2.41 × 10⁻⁴ to 2.41 mM), and monoethylene glycol di-ibuprofen (

Indexed as

anti-inflammatoryantioxidantcytotoxicityesterificationmultifunctional drugsnitric oxide inhibition

Identifiers

PMID40370604
PMCPMC12074795

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.